Highly selective chiral recognition on polymer supports: Preparation of a combinatorial library of dihydropyrimidines and its screening for novel chiral HPLC ligands

Kevin Lewandowski, Peter Murer, Frantisek Svec, Jean M.J. Fréchet*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

A library of more than 140 racemic 4-aryl-1,4-dihydropyrimidines has been synthesized using the single step Biginelli multicomponent condensation; the individual compounds were screened for enantiomer resolution, and the best candidate attached to a solid macroporous polymer support to afford a highly selective separation medium for chiral HPLC.

Original languageEnglish (US)
Pages (from-to)2237-2238
Number of pages2
JournalCHEMICAL COMMUNICATIONS
Issue number20
DOIs
StatePublished - Oct 21 1998
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • General Chemistry
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Catalysis

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