Highly Efficient Thermoresponsive Nanocomposite for Controlled Release Applications

Omar Yassine, Amir Zaher, Erqiang Li, Ahmed Alfadhel, Jose E. Perez, Mincho Kavaldzhiev, Maria F. Contreras, Sigurdur T Thoroddsen, Niveen M. Khashab, Jürgen Kosel

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Highly efficient magnetic release from nanocomposite microparticles is shown, which are made of Poly (N-isopropylacrylamide) hydrogel with embedded iron nanowires. A simple microfluidic technique was adopted to fabricate the microparticles with a high control of the nanowire concentration and in a relatively short time compared to chemical synthesis methods. The thermoresponsive microparticles were used for the remotely triggered release of Rhodamine (B). With a magnetic field of only 1 mT and 20 kHz a drug release of 6.5% and 70% was achieved in the continuous and pulsatile modes, respectively. Those release values are similar to the ones commonly obtained using superparamagnetic beads but accomplished with a magnetic field of five orders of magnitude lower power. The high efficiency is a result of the high remanent magnetization of the nanowires, which produce a large torque when exposed to a magnetic field. This causes the nanowires to vibrate, resulting in friction losses and heating. For comparison, microparticles with superparamagnetic beads were also fabricated and tested; while those worked at 73 mT and 600 kHz, no release was observed at the low field conditions. Cytotoxicity assays showed similar and high cell viability for microparticles with nanowires and beads.
Original languageEnglish (US)
JournalScientific Reports
Issue number1
StatePublished - Jun 23 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: Research reported in this publication was supported by the King Abdullah University of Science and Technology (KAUST). EQL is grateful for a SABIC Postdoctoral Fellowship.


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