Highly Aminated Mesoporous Silica Nanoparticles with Cubic Pore Structure

Teeraporn Suteewong, Hiroaki Sai, Roy Cohen, Suntao Wang, Michelle Bradbury, Barbara Baird, Sol M. Gruner, Ulrich Wiesner

Research output: Contribution to journalArticlepeer-review

113 Scopus citations


Mesoporous silica with cubic symmetry has attracted interest from researchers for some time. Here, we present the room temperature synthesis of mesoporous silica nanoparticles possessing cubic Pm3n symmetry with very high molar ratios (>50%) of 3-aminopropyl triethoxysilane. The synthesis is robust allowing, for example, co-condensation of organic dyes without loss of structure. By means of pore expander molecules, the pore size can be enlarged from 2.7 to 5 nm, while particle size decreases. Adding pore expander and co-condensing fluorescent dyes in the same synthesis reduces average particle size further down to 100 nm. After PEGylation, such fluorescent aminated mesoporous silica nanoparticles are spontaneously taken up by cells as demonstrated by fluorescence microscopy.
Original languageEnglish (US)
Pages (from-to)172-175
Number of pages4
JournalJournal of the American Chemical Society
Issue number2
StatePublished - Jan 19 2011
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by the Cornell Center for Materials Research (CCMR) with funding from a PREM program at Norfolk State University through the National Science Foundation (NSF) grant (DMR-0611430), by the Department of Energy grant DE-FG02-97ER62443 and by the National Institute of Dental and Craniofacial Research (R21DE018335). We thank the Cornell Universiy KAUST Center for Research and Education for financial support. This work was further supported by the U.S. Department of Homeland Security under Cooperative Agreement Number "2009-ST-108-LR0004". The authors thank CCMR for facility support. This work is based upon research conducted at the Cornell High Energy Synchrotron Source (CHESS), which is supported by the NSF and the National Institutes of Health/National Institute of General Medical Sciences under NSF award DMR-0225180. T.S. is grateful for a Thai Government Scholarship tinder the Ministry of Science and Technology.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.


Dive into the research topics of 'Highly Aminated Mesoporous Silica Nanoparticles with Cubic Pore Structure'. Together they form a unique fingerprint.

Cite this