Abstract
Block copolypeptides with their inherent nanometer length scale of phase separation, provide means of manipulating the type (α-helices, β-strands) and persistence of peptide secondary structures. Two such examples are employed based on the α-helical poly(γ-benzyl-l- glutamate) (PBLG) polypeptide as one block and poly(l-leucine) (α-helical) or poly(O-benzyl-l-tyrosine) (POBT) (β-strands) as the second block. Although both secondary structures are present in the copolypeptides the effect of nano-scale confinement is to induce folding in the POBT β-sheets and to maintain the defected α-helices of PBLG and PLEU with a limited lateral coherence.
Original language | English (US) |
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Pages (from-to) | 668-674 |
Number of pages | 7 |
Journal | European Polymer Journal |
Volume | 47 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2011 |
Externally published | Yes |
Keywords
- Copolypeptides
- Self-assembly
- α-Helices
- β-Strands
ASJC Scopus subject areas
- Materials Chemistry
- Polymers and Plastics
- General Physics and Astronomy
- Organic Chemistry