A dramatic enhancement of the diastereo- and enantioselectivity in the nitro-Michael addition reaction organocatalysed by a commercially available α,α-l-diaryl prolinol was disclosed when performing the reaction in unconventional hexafluorobenzene as a medium. DFT calculations were performed to clarify the origin of stereoselectivity and the role of C 6F 6. © The Royal Society of Chemistry 2012.
Bibliographical noteKAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We thank MIUR for financial support and the Spanish MICINN for a Ramon y Cajal contract (RYC-2009-04170).
ASJC Scopus subject areas
- Materials Chemistry
- Surfaces, Coatings and Films
- Metals and Alloys
- Ceramics and Composites
- Electronic, Optical and Magnetic Materials