Abstract
The enantioselective synthesis of α- and γ-tocopherol (the most biologically active members of vitamin E family) and analogues has been accomplished employing a new enantioselective gold catalyzed intramolecular allylic alkylation reaction followed by an olefin cross-metathesis as key steps. The methodology proved to be applicable to different olefins highlighting its potential for the synthesis of diverse libraries. The enantioselective synthesis of α- and γ-tocopherol (the most biologically active members of vitamin E family) and analogues has been accomplished employing an enantioselective gold-catalyzed intramolecular allylic alkylation reaction followed by an olefin cross-metathesis as key steps (see scheme).
Original language | English (US) |
---|---|
Pages (from-to) | 13913-13917 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 20 |
Issue number | 43 |
DOIs | |
State | Published - Oct 20 2014 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keywords
- Vitamin E
- allylic alkylation
- chromans
- gold catalysis
- tocopherol
ASJC Scopus subject areas
- Catalysis
- General Chemistry
- Organic Chemistry