Glial Energy Metabolism: Overview

L. Pellerin; Pierre Magistretti

doi:10.1016/B978-008045046-9.01708-3

Glial Energy Metabolism: Overview

L. Pellerin^*, Pierre Magistretti

^*Corresponding author for this work

Biological, Environmental Sciences and Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

Astrocytes exhibit several unique metabolic features. They possess a reserve glycolytic capacity that is used to cope with the burden of gultamate recycling. They contain glycogen stores that can be mobilized to face high energy demands following intense neuronal activity. Astrocytes also play a pivotal role in the protection against radical oxygen species, notably by providing precursors for the synthesis of glutathione to neurons. In addition, they are essential to replenish the neuronal glutamate pool and maintain glutamatergic transmission by providing the precursor gultamine synthesized either from recycled gultamate or . de novo from gulcose. Together with synaptic elements, astrocytes constitute a metabolic unit of fundamental importance to ensure excitatory neurotransmission.

Original language	English (US)
Title of host publication	Encyclopedia of Neuroscience
Publisher	Elsevier Ltd.
Pages	783-788
Number of pages	6
ISBN (Print)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.01708-3
State	Published - Jan 1 2009

Keywords

Astrocyte
Glutamate
Glutathione
Glycogen
Lactate

ASJC Scopus subject areas

General Neuroscience

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10.1016/B978-008045046-9.01708-3

Cite this

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title = "Glial Energy Metabolism: Overview",

abstract = "Astrocytes exhibit several unique metabolic features. They possess a reserve glycolytic capacity that is used to cope with the burden of gultamate recycling. They contain glycogen stores that can be mobilized to face high energy demands following intense neuronal activity. Astrocytes also play a pivotal role in the protection against radical oxygen species, notably by providing precursors for the synthesis of glutathione to neurons. In addition, they are essential to replenish the neuronal glutamate pool and maintain glutamatergic transmission by providing the precursor gultamine synthesized either from recycled gultamate or . de novo from gulcose. Together with synaptic elements, astrocytes constitute a metabolic unit of fundamental importance to ensure excitatory neurotransmission.",

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AU - Magistretti, Pierre

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AB - Astrocytes exhibit several unique metabolic features. They possess a reserve glycolytic capacity that is used to cope with the burden of gultamate recycling. They contain glycogen stores that can be mobilized to face high energy demands following intense neuronal activity. Astrocytes also play a pivotal role in the protection against radical oxygen species, notably by providing precursors for the synthesis of glutathione to neurons. In addition, they are essential to replenish the neuronal glutamate pool and maintain glutamatergic transmission by providing the precursor gultamine synthesized either from recycled gultamate or . de novo from gulcose. Together with synaptic elements, astrocytes constitute a metabolic unit of fundamental importance to ensure excitatory neurotransmission.

KW - Astrocyte

KW - Glutamate

KW - Glutathione

KW - Glycogen

KW - Lactate

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DO - 10.1016/B978-008045046-9.01708-3

M3 - Conference contribution

SN - 9780080450469

SP - 783

EP - 788

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd.

ER -

Glial Energy Metabolism: Overview

Abstract

Keywords

ASJC Scopus subject areas

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