Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens

Chih Hua Chao; Ju Chien Cheng; Théo P. Gonçalves; Kuo Wei Huang; Chi Chien Lin; Hui Chi Huang; Syh Yuan Hwang; Yang Chang Wu

doi:10.1038/s41598-018-33748-6

Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens

Chih Hua Chao^*, Ju Chien Cheng, Théo P. Gonçalves, Kuo Wei Huang, Chi Chien Lin, Hui Chi Huang, Syh Yuan Hwang, Yang Chang Wu

^*Corresponding author for this work

Chemistry

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7 Scopus citations

Abstract

Glaulactams A–C (1–3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by spectroscopic analyses and time-dependent density-functional-theory-calculated electronic circular dichroism spectra; the data were subsequently analyzed to gain insight into the respective biogenetic relationships between the isolates, which exhibited anti-H1N1 and immunosuppressive activities.

Original language	English (US)
Article number	15417
Journal	Scientific Reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-33748-6
State	Published - Dec 1 2018

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Publisher Copyright:
© 2018, The Author(s).

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title = "Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens",

abstract = "Glaulactams A–C (1–3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by spectroscopic analyses and time-dependent density-functional-theory-calculated electronic circular dichroism spectra; the data were subsequently analyzed to gain insight into the respective biogenetic relationships between the isolates, which exhibited anti-H1N1 and immunosuppressive activities.",

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AU - Chao, Chih Hua

AU - Cheng, Ju Chien

AU - Gonçalves, Théo P.

AU - Huang, Kuo Wei

AU - Lin, Chi Chien

AU - Huang, Hui Chi

AU - Hwang, Syh Yuan

AU - Wu, Yang Chang

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AB - Glaulactams A–C (1–3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by spectroscopic analyses and time-dependent density-functional-theory-calculated electronic circular dichroism spectra; the data were subsequently analyzed to gain insight into the respective biogenetic relationships between the isolates, which exhibited anti-H1N1 and immunosuppressive activities.

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Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens

Abstract

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