Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens

Chih Hua Chao*, Ju Chien Cheng, Théo P. Gonçalves, Kuo Wei Huang, Chi Chien Lin, Hui Chi Huang, Syh Yuan Hwang, Yang Chang Wu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Glaulactams A–C (1–3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by spectroscopic analyses and time-dependent density-functional-theory-calculated electronic circular dichroism spectra; the data were subsequently analyzed to gain insight into the respective biogenetic relationships between the isolates, which exhibited anti-H1N1 and immunosuppressive activities.

Original languageEnglish (US)
Article number15417
JournalScientific Reports
Issue number1
StatePublished - Dec 1 2018

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© 2018, The Author(s).

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