Ghrelin and food reward

Omar Al Massadi; Ruben Nogueiras; Carlos Dieguez; Jean-Antoine Girault

doi:10.1016/j.neuropharm.2019.01.001

Ghrelin and food reward

Omar Al Massadi, Ruben Nogueiras, Carlos Dieguez, Jean-Antoine Girault

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Food intake is tightly regulated by homeostatic and reward mechanisms and the adequate function of both is necessary for the proper maintenance of energy balance. Ghrelin impacts on these two levels to induce feeding. In this review, we present the actions of ghrelin in food reward, including their dependence on other relevant modulators implicated in the motivational aspects of feeding, including dopamine, opioid peptides, and endocannabinoids. We also describe the interaction between brain areas involved in homeostatic regulation of feeding and the reward system, with a special emphasis on the role of arcuate nucleus melanocortins and lateral hypothalamus orexins in ghrelin function. Finally, we briefly discuss the actions of ghrelin in food reward in obesity. We propose that new insights into the mechanism of action of ghrelin in the rewarding and motivational control of food intake will help to understand food-related disorders including obesity and anorexia.

Original language	English (US)
Pages (from-to)	131-138
Number of pages	8
Journal	Neuropharmacology
Volume	148
DOIs	https://doi.org/10.1016/j.neuropharm.2019.01.001
State	Published - Apr 2019
Externally published	Yes

Bibliographical note

KAUST Repository Item: Exported on 2021-03-12
Acknowledged KAUST grant number(s): OSR-2015-CRG4-2602
Acknowledgements: Work in the laboratory of JAG is supported by Inserm, Sorbonne Université (formerly Université Pierre et Marie Curie, UPMC, Paris-6), and grants from ANR MALZ-2013, the King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research award (#OSR-2015-CRG4-2602), Fondation pour la Recherche Médicale and Labex Bio-Psy. Work in the laboratory of RN and CD is supported by grants from MINECO (CD BFU2017-87721 and RN: BFU2015-70664R); Xunta de Galicia (RN: 2015-CP080 and 2016-PG057), and Centro de Investigación Biomédica en Red (CIBER) de Fisiopatología de la Obesidad y Nutrición (CIBERobn). CIBERobn is an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER funds. O.A-M is funded by the ISCIII/SERGAS through a research contract “Sara Borrell” (CD14/00091). The figures were generated by using materials from Servier Medical Art (Servier) under consideration of a Creative Commons Attribution 3.0 Unported License.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.neuropharm.2019.01.001

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title = "Ghrelin and food reward",

abstract = "Food intake is tightly regulated by homeostatic and reward mechanisms and the adequate function of both is necessary for the proper maintenance of energy balance. Ghrelin impacts on these two levels to induce feeding. In this review, we present the actions of ghrelin in food reward, including their dependence on other relevant modulators implicated in the motivational aspects of feeding, including dopamine, opioid peptides, and endocannabinoids. We also describe the interaction between brain areas involved in homeostatic regulation of feeding and the reward system, with a special emphasis on the role of arcuate nucleus melanocortins and lateral hypothalamus orexins in ghrelin function. Finally, we briefly discuss the actions of ghrelin in food reward in obesity. We propose that new insights into the mechanism of action of ghrelin in the rewarding and motivational control of food intake will help to understand food-related disorders including obesity and anorexia.",

author = "{Al Massadi}, Omar and Ruben Nogueiras and Carlos Dieguez and Jean-Antoine Girault",

note = "KAUST Repository Item: Exported on 2021-03-12 Acknowledged KAUST grant number(s): OSR-2015-CRG4-2602 Acknowledgements: Work in the laboratory of JAG is supported by Inserm, Sorbonne Universit{\'e} (formerly Universit{\'e} Pierre et Marie Curie, UPMC, Paris-6), and grants from ANR MALZ-2013, the King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research award (#OSR-2015-CRG4-2602), Fondation pour la Recherche M{\'e}dicale and Labex Bio-Psy. Work in the laboratory of RN and CD is supported by grants from MINECO (CD BFU2017-87721 and RN: BFU2015-70664R); Xunta de Galicia (RN: 2015-CP080 and 2016-PG057), and Centro de Investigaci{\'o}n Biom{\'e}dica en Red (CIBER) de Fisiopatolog{\'i}a de la Obesidad y Nutrici{\'o}n (CIBERobn). CIBERobn is an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER funds. O.A-M is funded by the ISCIII/SERGAS through a research contract “Sara Borrell” (CD14/00091). The figures were generated by using materials from Servier Medical Art (Servier) under consideration of a Creative Commons Attribution 3.0 Unported License. This publication acknowledges KAUST support, but has no KAUST affiliated authors.",

year = "2019",

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doi = "10.1016/j.neuropharm.2019.01.001",

language = "English (US)",

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AU - Al Massadi, Omar

AU - Nogueiras, Ruben

AU - Dieguez, Carlos

AU - Girault, Jean-Antoine

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N2 - Food intake is tightly regulated by homeostatic and reward mechanisms and the adequate function of both is necessary for the proper maintenance of energy balance. Ghrelin impacts on these two levels to induce feeding. In this review, we present the actions of ghrelin in food reward, including their dependence on other relevant modulators implicated in the motivational aspects of feeding, including dopamine, opioid peptides, and endocannabinoids. We also describe the interaction between brain areas involved in homeostatic regulation of feeding and the reward system, with a special emphasis on the role of arcuate nucleus melanocortins and lateral hypothalamus orexins in ghrelin function. Finally, we briefly discuss the actions of ghrelin in food reward in obesity. We propose that new insights into the mechanism of action of ghrelin in the rewarding and motivational control of food intake will help to understand food-related disorders including obesity and anorexia.

AB - Food intake is tightly regulated by homeostatic and reward mechanisms and the adequate function of both is necessary for the proper maintenance of energy balance. Ghrelin impacts on these two levels to induce feeding. In this review, we present the actions of ghrelin in food reward, including their dependence on other relevant modulators implicated in the motivational aspects of feeding, including dopamine, opioid peptides, and endocannabinoids. We also describe the interaction between brain areas involved in homeostatic regulation of feeding and the reward system, with a special emphasis on the role of arcuate nucleus melanocortins and lateral hypothalamus orexins in ghrelin function. Finally, we briefly discuss the actions of ghrelin in food reward in obesity. We propose that new insights into the mechanism of action of ghrelin in the rewarding and motivational control of food intake will help to understand food-related disorders including obesity and anorexia.

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DO - 10.1016/j.neuropharm.2019.01.001

M3 - Article

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VL - 148

SP - 131

EP - 138

JO - Neuropharmacology

JF - Neuropharmacology

ER -

Ghrelin and food reward

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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