Genomic analysis of the causative agents of coccidiosis in domestic chickens

Adam J. Reid; Damer P. Blake; Hifzur Rahman Ansari; Karen Billington; Hilary P. Browne; Josephine Bryant; Matt Dunn; Stacy S. Hung; Fumiya Kawahara; Diego Miranda-Saavedra; Tareq Majed Yasin Malas; Tobias Mourier; Hardeep Naghra; Mridul Nair; Thomas D. Otto; Neil D. Rawlings; Pierre Rivailler; Alejandro Sanchez-Flores; Mandy Sanders; Chandra Subramaniam; Yea-Ling Tay; Yong Woo; Xikun Wu; Bart Barrell; Paul H. Dear; Christian Doerig; Arthur Gruber; Alasdair C. Ivens; John Parkinson; Marie-Adèle Rajandream; Martin W. Shirley; Kiew-Lian Wan; Matthew Berriman; Fiona M. Tomley; Arnab Pain

doi:10.1101/gr.168955.113

Genomic analysis of the causative agents of coccidiosis in domestic chickens

Adam J. Reid, Damer P. Blake, Hifzur Rahman Ansari, Karen Billington, Hilary P. Browne, Josephine Bryant, Matt Dunn, Stacy S. Hung, Fumiya Kawahara, Diego Miranda-Saavedra, Tareq Majed Yasin Malas, Tobias Mourier, Hardeep Naghra, Mridul Nair, Thomas D. Otto, Neil D. Rawlings, Pierre Rivailler, Alejandro Sanchez-Flores, Mandy Sanders, Chandra SubramaniamYea-Ling Tay, Yong Woo, Xikun Wu, Bart Barrell, Paul H. Dear, Christian Doerig, Arthur Gruber, Alasdair C. Ivens, John Parkinson, Marie-Adèle Rajandream, Martin W. Shirley, Kiew-Lian Wan, Matthew Berriman, Fiona M. Tomley, Arnab Pain

Research output: Contribution to journal › Article › peer-review

172 Scopus citations

Abstract

Global production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of the most important poultry diseases. Understanding the biology of Eimeria parasites underpins development of new drugs and vaccines needed to improve global food security. We have produced annotated genome sequences of all seven species of Eimeria that infect domestic chickens, which reveal the full extent of previously described repeat-rich and repeat-poor regions and show that these parasites possess the most repeat-rich proteomes ever described. Furthermore, while no other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromoviruses. Analysis of Eimeria genes involved in basic biology and host-parasite interaction highlights adaptations to a relatively simple developmental life cycle and a complex array of co-expressed surface proteins involved in host cell binding.

Original language	English (US)
Pages (from-to)	1676-1685
Number of pages	10
Journal	Genome Research
Volume	24
Issue number	10
DOIs	https://doi.org/10.1101/gr.168955.113
State	Published - Jul 11 2014

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01

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10.1101/gr.168955.113

https://repository.kaust.edu.sa/bitstream/10754/346998/1/Genome%20Res.-2014-Reid-1676-85.pdf

Cite this

Reid, A. J., Blake, D. P., Ansari, H. R., Billington, K., Browne, H. P., Bryant, J., Dunn, M., Hung, S. S., Kawahara, F., Miranda-Saavedra, D., Malas, T. M. Y., Mourier, T., Naghra, H., Nair, M., Otto, T. D., Rawlings, N. D., Rivailler, P., Sanchez-Flores, A., Sanders, M., ... Pain, A. (2014). Genomic analysis of the causative agents of coccidiosis in domestic chickens. Genome Research, 24(10), 1676-1685. https://doi.org/10.1101/gr.168955.113

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title = "Genomic analysis of the causative agents of coccidiosis in domestic chickens",

abstract = "Global production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of the most important poultry diseases. Understanding the biology of Eimeria parasites underpins development of new drugs and vaccines needed to improve global food security. We have produced annotated genome sequences of all seven species of Eimeria that infect domestic chickens, which reveal the full extent of previously described repeat-rich and repeat-poor regions and show that these parasites possess the most repeat-rich proteomes ever described. Furthermore, while no other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromoviruses. Analysis of Eimeria genes involved in basic biology and host-parasite interaction highlights adaptations to a relatively simple developmental life cycle and a complex array of co-expressed surface proteins involved in host cell binding.",

author = "Reid, {Adam J.} and Blake, {Damer P.} and Ansari, {Hifzur Rahman} and Karen Billington and Browne, {Hilary P.} and Josephine Bryant and Matt Dunn and Hung, {Stacy S.} and Fumiya Kawahara and Diego Miranda-Saavedra and Malas, {Tareq Majed Yasin} and Tobias Mourier and Hardeep Naghra and Mridul Nair and Otto, {Thomas D.} and Rawlings, {Neil D.} and Pierre Rivailler and Alejandro Sanchez-Flores and Mandy Sanders and Chandra Subramaniam and Yea-Ling Tay and Yong Woo and Xikun Wu and Bart Barrell and Dear, {Paul H.} and Christian Doerig and Arthur Gruber and Ivens, {Alasdair C.} and John Parkinson and Marie-Ad{\`e}le Rajandream and Shirley, {Martin W.} and Kiew-Lian Wan and Matthew Berriman and Tomley, {Fiona M.} and Arnab Pain",

note = "KAUST Repository Item: Exported on 2020-10-01",

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Reid, AJ, Blake, DP, Ansari, HR, Billington, K, Browne, HP, Bryant, J, Dunn, M, Hung, SS, Kawahara, F, Miranda-Saavedra, D, Malas, TMY, Mourier, T, Naghra, H, Nair, M, Otto, TD, Rawlings, ND, Rivailler, P, Sanchez-Flores, A, Sanders, M, Subramaniam, C, Tay, Y-L, Woo, Y, Wu, X, Barrell, B, Dear, PH, Doerig, C, Gruber, A, Ivens, AC, Parkinson, J, Rajandream, M-A, Shirley, MW, Wan, K-L, Berriman, M, Tomley, FM & Pain, A 2014, 'Genomic analysis of the causative agents of coccidiosis in domestic chickens', Genome Research, vol. 24, no. 10, pp. 1676-1685. https://doi.org/10.1101/gr.168955.113

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T1 - Genomic analysis of the causative agents of coccidiosis in domestic chickens

AU - Reid, Adam J.

AU - Blake, Damer P.

AU - Ansari, Hifzur Rahman

AU - Billington, Karen

AU - Browne, Hilary P.

AU - Bryant, Josephine

AU - Dunn, Matt

AU - Hung, Stacy S.

AU - Kawahara, Fumiya

AU - Miranda-Saavedra, Diego

AU - Malas, Tareq Majed Yasin

AU - Mourier, Tobias

AU - Naghra, Hardeep

AU - Nair, Mridul

AU - Otto, Thomas D.

AU - Rawlings, Neil D.

AU - Rivailler, Pierre

AU - Sanchez-Flores, Alejandro

AU - Sanders, Mandy

AU - Subramaniam, Chandra

AU - Tay, Yea-Ling

AU - Woo, Yong

AU - Wu, Xikun

AU - Barrell, Bart

AU - Dear, Paul H.

AU - Doerig, Christian

AU - Gruber, Arthur

AU - Ivens, Alasdair C.

AU - Parkinson, John

AU - Rajandream, Marie-Adèle

AU - Shirley, Martin W.

AU - Wan, Kiew-Lian

AU - Berriman, Matthew

AU - Tomley, Fiona M.

AU - Pain, Arnab

N1 - KAUST Repository Item: Exported on 2020-10-01

PY - 2014/7/11

Y1 - 2014/7/11

N2 - Global production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of the most important poultry diseases. Understanding the biology of Eimeria parasites underpins development of new drugs and vaccines needed to improve global food security. We have produced annotated genome sequences of all seven species of Eimeria that infect domestic chickens, which reveal the full extent of previously described repeat-rich and repeat-poor regions and show that these parasites possess the most repeat-rich proteomes ever described. Furthermore, while no other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromoviruses. Analysis of Eimeria genes involved in basic biology and host-parasite interaction highlights adaptations to a relatively simple developmental life cycle and a complex array of co-expressed surface proteins involved in host cell binding.

AB - Global production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of the most important poultry diseases. Understanding the biology of Eimeria parasites underpins development of new drugs and vaccines needed to improve global food security. We have produced annotated genome sequences of all seven species of Eimeria that infect domestic chickens, which reveal the full extent of previously described repeat-rich and repeat-poor regions and show that these parasites possess the most repeat-rich proteomes ever described. Furthermore, while no other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromoviruses. Analysis of Eimeria genes involved in basic biology and host-parasite interaction highlights adaptations to a relatively simple developmental life cycle and a complex array of co-expressed surface proteins involved in host cell binding.

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UR - http://genome.cshlp.org/lookup/doi/10.1101/gr.168955.113

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DO - 10.1101/gr.168955.113

M3 - Article

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SN - 1088-9051

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SP - 1676

EP - 1685

JO - Genome Research

JF - Genome Research

IS - 10

ER -

Genomic analysis of the causative agents of coccidiosis in domestic chickens

Abstract

Bibliographical note

UN SDGs

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