Genome sequence of the tsetse fly (Glossina morsitans ): Vector of African trypanosomiasis

Junichi Watanabe; Masahira Hattori; Matthew Berriman; Michael J. Lehane; Neil Hall; Philippe Solano; Serap Aksoy; Winston Hide; Yéya Tiémoko Touré; Geoffrey M. Attardo; Alistair Charles Darby; Atsushi Toyoda; Christiane Hertz-Fowler; Denis M. Larkin; James A. Cotton; Mandy J. Sanders; Martin T. Swain; Michael A. Quail; Noboru Inoue; Sophie Ravel; Todd Duane Taylor; Tulika P. Srivastava; Vineet Kumar Sharma; Wesley C. Warren; Richard K. Wilson; Yutaka Suzuki; Daniel Lawson; Daniel Seth Toney Hughes; Karyn Megy; Daniel K. Masiga; Paul Odhiambo Mireji; Immo Alex Hansen; Jan Van Den Abbeele; Joshua B. Benoit; Kostas Bourtzis; George F O Obiero; Hugh M. Robertson; Jeffery W. Jones; Jingjiang Zhou; Linda M. Field; Markus Friedrich; Steven R G Nyanjom; Erich Loza Telleria; Guy Caljon; José M. C. Ribeiro; Alvaro Acosta-Serrano; Cherpheng Ooi; Clair Rose; David P. Price; Lee Rafuse Haines; Alan G. Christoffels; Cheolho Sim; Daphne Q D Pham; David L. Denlinger; Dawn L. Geiser; Irene A. Omedo; Joy J. Winzerling; Justin T. Peyton; Kevin K. Marucha; Mario Jonas; Megan E. Meuti; Neil David Rawlings; Qirui Zhang; Rosaline Wanjiru Macharia; Veronika Michalkova; Zahra Jalali Sefid Dashti; Aaron A. Baumann; Gerd Gäde; Heather G. Marco; Jelle Caers; Liliane Schoofs; Michael A. Riehle; Wanqi Hu; Zhijian Tu; Aaron M. Tarone; Anna Rodolfa Malacrida; Caleb K. Kibet; Francesca Scolari; J. J. O. Koekemoer; Judith H. Willis; Ludvik M. Gomulski; Marco Falchetto; Maxwell J. Scott; Shuhua Fu; Singhoi Sze; Thiago Luiz; Brian L. Weiss; Deirdre P. Walshe; Jingwen Wang; Mark Wamalwa; Sarah Mwangi; Urvashi N. Ramphul; Anna K. Snyder; Corey L. Brelsfoard; Gavin H. Thomas; George Tsiamis; Peter Arensburger; Rita V M Rio; Sandy J. Macdonald; Sumir Panji; Adele F. Kruger; Alia Benkahla; Apollo Simon Peter Balyeidhusa; Atway R. Msangi; Chinyere K. Okoro; Dawn Stephens; Eleanor J. Stanley; Feziwe Mpondo; Florence N. Wamwiri; Furaha Mramba; Geoffrey H. Siwo; George Githinji; Gordon William Harkins; Grace Adira Murilla; Heikki Lehväslaiho; Imna I. Malele; Joanna Eseri Auma; Johnson K. Kinyua; Johnson O. Ouma; Loyce M A Okedi; Lucien Manga; Martin A. Aslett; Mathurin Koffi; Michael W. Gaunt; Mmule Makgamathe; Nicola Jane Mulder; Oliver Manangwa; Patrick P. Abila; Patrick Wincker; Richard I. Gregory; Rosemary Bateta; Ryuichi Sakate; Sheila Ommeh; Stella M. Lehane; Tadashi Imanishi; Victor Chukwudi Osamor; Yoshihiro Kawahara

doi:10.1126/science.1249656

Genome sequence of the tsetse fly (Glossina morsitans ): Vector of African trypanosomiasis

Junichi Watanabe, Masahira Hattori, Matthew Berriman, Michael J. Lehane, Neil Hall, Philippe Solano, Serap Aksoy, Winston Hide, Yéya Tiémoko Touré, Geoffrey M. Attardo, Alistair Charles Darby, Atsushi Toyoda, Christiane Hertz-Fowler, Denis M. Larkin, James A. Cotton, Mandy J. Sanders, Martin T. Swain, Michael A. Quail, Noboru Inoue, Sophie RavelTodd Duane Taylor, Tulika P. Srivastava, Vineet Kumar Sharma, Wesley C. Warren, Richard K. Wilson, Yutaka Suzuki, Daniel Lawson, Daniel Seth Toney Hughes, Karyn Megy, Daniel K. Masiga, Paul Odhiambo Mireji, Immo Alex Hansen, Jan Van Den Abbeele, Joshua B. Benoit, Kostas Bourtzis, George F O Obiero, Hugh M. Robertson, Jeffery W. Jones, Jingjiang Zhou, Linda M. Field, Markus Friedrich, Steven R G Nyanjom, Erich Loza Telleria, Guy Caljon, José M. C. Ribeiro, Alvaro Acosta-Serrano, Cherpheng Ooi, Clair Rose, David P. Price, Lee Rafuse Haines, Alan G. Christoffels, Cheolho Sim, Daphne Q D Pham, David L. Denlinger, Dawn L. Geiser, Irene A. Omedo, Joy J. Winzerling, Justin T. Peyton, Kevin K. Marucha, Mario Jonas, Megan E. Meuti, Neil David Rawlings, Qirui Zhang, Rosaline Wanjiru Macharia, Veronika Michalkova, Zahra Jalali Sefid Dashti, Aaron A. Baumann, Gerd Gäde, Heather G. Marco, Jelle Caers, Liliane Schoofs, Michael A. Riehle, Wanqi Hu, Zhijian Tu, Aaron M. Tarone, Anna Rodolfa Malacrida, Caleb K. Kibet, Francesca Scolari, J. J. O. Koekemoer, Judith H. Willis, Ludvik M. Gomulski, Marco Falchetto, Maxwell J. Scott, Shuhua Fu, Singhoi Sze, Thiago Luiz, Brian L. Weiss, Deirdre P. Walshe, Jingwen Wang, Mark Wamalwa, Sarah Mwangi, Urvashi N. Ramphul, Anna K. Snyder, Corey L. Brelsfoard, Gavin H. Thomas, George Tsiamis, Peter Arensburger, Rita V M Rio, Sandy J. Macdonald, Sumir Panji, Adele F. Kruger, Alia Benkahla, Apollo Simon Peter Balyeidhusa, Atway R. Msangi, Chinyere K. Okoro, Dawn Stephens, Eleanor J. Stanley, Feziwe Mpondo, Florence N. Wamwiri, Furaha Mramba, Geoffrey H. Siwo, George Githinji, Gordon William Harkins, Grace Adira Murilla, Heikki Lehväslaiho, Imna I. Malele, Joanna Eseri Auma, Johnson K. Kinyua, Johnson O. Ouma, Loyce M A Okedi, Lucien Manga, Martin A. Aslett, Mathurin Koffi, Michael W. Gaunt, Mmule Makgamathe, Nicola Jane Mulder, Oliver Manangwa, Patrick P. Abila, Patrick Wincker, Richard I. Gregory, Rosemary Bateta, Ryuichi Sakate, Sheila Ommeh, Stella M. Lehane, Tadashi Imanishi, Victor Chukwudi Osamor, Yoshihiro Kawahara

Biological, Environmental Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

194 Scopus citations

Abstract

Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.

Original language	English (US)
Pages (from-to)	380-386
Number of pages	7
Journal	Science
Volume	344
Issue number	6182
DOIs	https://doi.org/10.1126/science.1249656
State	Published - Apr 24 2014

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The public release and future updates of the genome sequence and associated information are hosted at VectorBase (www.vectorbase.org). The genome sequence can also be found at GenBank under the accession no. CCAG010000000. The Glossina morsitans genome project was funded by the Wellcome Trust (grants 085775/Z/08/Z and 098051) and World Health Organization (WHO) Special Programme for Research and Training in Tropical Diseases (TDR) (project no. A90088) and the Ambrose Monell Foundation. Authors also acknowledge support by the Food and Agriculture Organization/International Atomic Energy Agency Coordinated Research Program "Improving SIT for Tsetse Flies through Research on their Symbionts," the European Union Cooperation in Science and Technology (COST) Action FA0701 "Arthropod Symbiosis: From Fundamental Studies to Pest and Disease Management," and a grant-in-aid for Scientific Research on Priority Areas "Comprehensive Genomics" from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (to M. H.). BAC libraries were generated through National Institute of Allergy and Infectious Diseases resources, and sequencing was supported by RIKEN Japan. We thank the staff in the library construction, sequence production, and informatics support groups at the Wellcome Trust Sanger Institute.

ASJC Scopus subject areas

General

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1126/science.1249656

https://repository.kaust.edu.sa/bitstream/10754/563509/1/Articlefile1.pdf

Cite this

Watanabe, J., Hattori, M., Berriman, M., Lehane, M. J., Hall, N., Solano, P., Aksoy, S., Hide, W., Touré, Y. T., Attardo, G. M., Darby, A. C., Toyoda, A., Hertz-Fowler, C., Larkin, D. M., Cotton, J. A., Sanders, M. J., Swain, M. T., Quail, M. A., Inoue, N., ... Kawahara, Y. (2014). Genome sequence of the tsetse fly (Glossina morsitans ): Vector of African trypanosomiasis. Science, 344(6182), 380-386. https://doi.org/10.1126/science.1249656

@article{d2b4af1fc57e450ea46a9e0124b99dfb,

title = "Genome sequence of the tsetse fly (Glossina morsitans ): Vector of African trypanosomiasis",

abstract = "Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.",

author = "Junichi Watanabe and Masahira Hattori and Matthew Berriman and Lehane, {Michael J.} and Neil Hall and Philippe Solano and Serap Aksoy and Winston Hide and Tour{\'e}, {Y{\'e}ya Ti{\'e}moko} and Attardo, {Geoffrey M.} and Darby, {Alistair Charles} and Atsushi Toyoda and Christiane Hertz-Fowler and Larkin, {Denis M.} and Cotton, {James A.} and Sanders, {Mandy J.} and Swain, {Martin T.} and Quail, {Michael A.} and Noboru Inoue and Sophie Ravel and Taylor, {Todd Duane} and Srivastava, {Tulika P.} and Sharma, {Vineet Kumar} and Warren, {Wesley C.} and Wilson, {Richard K.} and Yutaka Suzuki and Daniel Lawson and Hughes, {Daniel Seth Toney} and Karyn Megy and Masiga, {Daniel K.} and Mireji, {Paul Odhiambo} and Hansen, {Immo Alex} and {Van Den Abbeele}, Jan and Benoit, {Joshua B.} and Kostas Bourtzis and Obiero, {George F O} and Robertson, {Hugh M.} and Jones, {Jeffery W.} and Jingjiang Zhou and Field, {Linda M.} and Markus Friedrich and Nyanjom, {Steven R G} and Telleria, {Erich Loza} and Guy Caljon and Ribeiro, {Jos{\'e} M. C.} and Alvaro Acosta-Serrano and Cherpheng Ooi and Clair Rose and Price, {David P.} and Haines, {Lee Rafuse} and Christoffels, {Alan G.} and Cheolho Sim and Pham, {Daphne Q D} and Denlinger, {David L.} and Geiser, {Dawn L.} and Omedo, {Irene A.} and Winzerling, {Joy J.} and Peyton, {Justin T.} and Marucha, {Kevin K.} and Mario Jonas and Meuti, {Megan E.} and Rawlings, {Neil David} and Qirui Zhang and Macharia, {Rosaline Wanjiru} and Veronika Michalkova and Dashti, {Zahra Jalali Sefid} and Baumann, {Aaron A.} and Gerd G{\"a}de and Marco, {Heather G.} and Jelle Caers and Liliane Schoofs and Riehle, {Michael A.} and Wanqi Hu and Zhijian Tu and Tarone, {Aaron M.} and Malacrida, {Anna Rodolfa} and Kibet, {Caleb K.} and Francesca Scolari and Koekemoer, {J. J. O.} and Willis, {Judith H.} and Gomulski, {Ludvik M.} and Marco Falchetto and Scott, {Maxwell J.} and Shuhua Fu and Singhoi Sze and Thiago Luiz and Weiss, {Brian L.} and Walshe, {Deirdre P.} and Jingwen Wang and Mark Wamalwa and Sarah Mwangi and Ramphul, {Urvashi N.} and Snyder, {Anna K.} and Brelsfoard, {Corey L.} and Thomas, {Gavin H.} and George Tsiamis and Peter Arensburger and Rio, {Rita V M} and Macdonald, {Sandy J.} and Sumir Panji and Kruger, {Adele F.} and Alia Benkahla and Balyeidhusa, {Apollo Simon Peter} and Msangi, {Atway R.} and Okoro, {Chinyere K.} and Dawn Stephens and Stanley, {Eleanor J.} and Feziwe Mpondo and Wamwiri, {Florence N.} and Furaha Mramba and Siwo, {Geoffrey H.} and George Githinji and Harkins, {Gordon William} and Murilla, {Grace Adira} and Heikki Lehv{\"a}slaiho and Malele, {Imna I.} and Auma, {Joanna Eseri} and Kinyua, {Johnson K.} and Ouma, {Johnson O.} and Okedi, {Loyce M A} and Lucien Manga and Aslett, {Martin A.} and Mathurin Koffi and Gaunt, {Michael W.} and Mmule Makgamathe and Mulder, {Nicola Jane} and Oliver Manangwa and Abila, {Patrick P.} and Patrick Wincker and Gregory, {Richard I.} and Rosemary Bateta and Ryuichi Sakate and Sheila Ommeh and Lehane, {Stella M.} and Tadashi Imanishi and Osamor, {Victor Chukwudi} and Yoshihiro Kawahara",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The public release and future updates of the genome sequence and associated information are hosted at VectorBase (www.vectorbase.org). The genome sequence can also be found at GenBank under the accession no. CCAG010000000. The Glossina morsitans genome project was funded by the Wellcome Trust (grants 085775/Z/08/Z and 098051) and World Health Organization (WHO) Special Programme for Research and Training in Tropical Diseases (TDR) (project no. A90088) and the Ambrose Monell Foundation. Authors also acknowledge support by the Food and Agriculture Organization/International Atomic Energy Agency Coordinated Research Program {"}Improving SIT for Tsetse Flies through Research on their Symbionts,{"} the European Union Cooperation in Science and Technology (COST) Action FA0701 {"}Arthropod Symbiosis: From Fundamental Studies to Pest and Disease Management,{"} and a grant-in-aid for Scientific Research on Priority Areas {"}Comprehensive Genomics{"} from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (to M. H.). BAC libraries were generated through National Institute of Allergy and Infectious Diseases resources, and sequencing was supported by RIKEN Japan. We thank the staff in the library construction, sequence production, and informatics support groups at the Wellcome Trust Sanger Institute.",

year = "2014",

month = apr,

day = "24",

doi = "10.1126/science.1249656",

language = "English (US)",

volume = "344",

pages = "380--386",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6182",

}

Watanabe, J, Hattori, M, Berriman, M, Lehane, MJ, Hall, N, Solano, P, Aksoy, S, Hide, W, Touré, YT, Attardo, GM, Darby, AC, Toyoda, A, Hertz-Fowler, C, Larkin, DM, Cotton, JA, Sanders, MJ, Swain, MT, Quail, MA, Inoue, N, Ravel, S, Taylor, TD, Srivastava, TP, Sharma, VK, Warren, WC, Wilson, RK, Suzuki, Y, Lawson, D, Hughes, DST, Megy, K, Masiga, DK, Mireji, PO, Hansen, IA, Van Den Abbeele, J, Benoit, JB, Bourtzis, K, Obiero, GFO, Robertson, HM, Jones, JW, Zhou, J, Field, LM, Friedrich, M, Nyanjom, SRG, Telleria, EL, Caljon, G, Ribeiro, JMC, Acosta-Serrano, A, Ooi, C, Rose, C, Price, DP, Haines, LR, Christoffels, AG, Sim, C, Pham, DQD, Denlinger, DL, Geiser, DL, Omedo, IA, Winzerling, JJ, Peyton, JT, Marucha, KK, Jonas, M, Meuti, ME, Rawlings, ND, Zhang, Q, Macharia, RW, Michalkova, V, Dashti, ZJS, Baumann, AA, Gäde, G, Marco, HG, Caers, J, Schoofs, L, Riehle, MA, Hu, W, Tu, Z, Tarone, AM, Malacrida, AR, Kibet, CK, Scolari, F, Koekemoer, JJO, Willis, JH, Gomulski, LM, Falchetto, M, Scott, MJ, Fu, S, Sze, S, Luiz, T, Weiss, BL, Walshe, DP, Wang, J, Wamalwa, M, Mwangi, S, Ramphul, UN, Snyder, AK, Brelsfoard, CL, Thomas, GH, Tsiamis, G, Arensburger, P, Rio, RVM, Macdonald, SJ, Panji, S, Kruger, AF, Benkahla, A, Balyeidhusa, ASP, Msangi, AR, Okoro, CK, Stephens, D, Stanley, EJ, Mpondo, F, Wamwiri, FN, Mramba, F, Siwo, GH, Githinji, G, Harkins, GW, Murilla, GA, Lehväslaiho, H, Malele, II, Auma, JE, Kinyua, JK, Ouma, JO, Okedi, LMA, Manga, L, Aslett, MA, Koffi, M, Gaunt, MW, Makgamathe, M, Mulder, NJ, Manangwa, O, Abila, PP, Wincker, P, Gregory, RI, Bateta, R, Sakate, R, Ommeh, S, Lehane, SM, Imanishi, T, Osamor, VC & Kawahara, Y 2014, 'Genome sequence of the tsetse fly (Glossina morsitans ): Vector of African trypanosomiasis', Science, vol. 344, no. 6182, pp. 380-386. https://doi.org/10.1126/science.1249656

TY - JOUR

T1 - Genome sequence of the tsetse fly (Glossina morsitans ): Vector of African trypanosomiasis

AU - Watanabe, Junichi

AU - Hattori, Masahira

AU - Berriman, Matthew

AU - Lehane, Michael J.

AU - Hall, Neil

AU - Solano, Philippe

AU - Aksoy, Serap

AU - Hide, Winston

AU - Touré, Yéya Tiémoko

AU - Attardo, Geoffrey M.

AU - Darby, Alistair Charles

AU - Toyoda, Atsushi

AU - Hertz-Fowler, Christiane

AU - Larkin, Denis M.

AU - Cotton, James A.

AU - Sanders, Mandy J.

AU - Swain, Martin T.

AU - Quail, Michael A.

AU - Inoue, Noboru

AU - Ravel, Sophie

AU - Taylor, Todd Duane

AU - Srivastava, Tulika P.

AU - Sharma, Vineet Kumar

AU - Warren, Wesley C.

AU - Wilson, Richard K.

AU - Suzuki, Yutaka

AU - Lawson, Daniel

AU - Hughes, Daniel Seth Toney

AU - Megy, Karyn

AU - Masiga, Daniel K.

AU - Mireji, Paul Odhiambo

AU - Hansen, Immo Alex

AU - Van Den Abbeele, Jan

AU - Benoit, Joshua B.

AU - Bourtzis, Kostas

AU - Obiero, George F O

AU - Robertson, Hugh M.

AU - Jones, Jeffery W.

AU - Zhou, Jingjiang

AU - Field, Linda M.

AU - Friedrich, Markus

AU - Nyanjom, Steven R G

AU - Telleria, Erich Loza

AU - Caljon, Guy

AU - Ribeiro, José M. C.

AU - Acosta-Serrano, Alvaro

AU - Ooi, Cherpheng

AU - Rose, Clair

AU - Price, David P.

AU - Haines, Lee Rafuse

AU - Christoffels, Alan G.

AU - Sim, Cheolho

AU - Pham, Daphne Q D

AU - Denlinger, David L.

AU - Geiser, Dawn L.

AU - Omedo, Irene A.

AU - Winzerling, Joy J.

AU - Peyton, Justin T.

AU - Marucha, Kevin K.

AU - Jonas, Mario

AU - Meuti, Megan E.

AU - Rawlings, Neil David

AU - Zhang, Qirui

AU - Macharia, Rosaline Wanjiru

AU - Michalkova, Veronika

AU - Dashti, Zahra Jalali Sefid

AU - Baumann, Aaron A.

AU - Gäde, Gerd

AU - Marco, Heather G.

AU - Caers, Jelle

AU - Schoofs, Liliane

AU - Riehle, Michael A.

AU - Hu, Wanqi

AU - Tu, Zhijian

AU - Tarone, Aaron M.

AU - Malacrida, Anna Rodolfa

AU - Kibet, Caleb K.

AU - Scolari, Francesca

AU - Koekemoer, J. J. O.

AU - Willis, Judith H.

AU - Gomulski, Ludvik M.

AU - Falchetto, Marco

AU - Scott, Maxwell J.

AU - Fu, Shuhua

AU - Sze, Singhoi

AU - Luiz, Thiago

AU - Weiss, Brian L.

AU - Walshe, Deirdre P.

AU - Wang, Jingwen

AU - Wamalwa, Mark

AU - Mwangi, Sarah

AU - Ramphul, Urvashi N.

AU - Snyder, Anna K.

AU - Brelsfoard, Corey L.

AU - Thomas, Gavin H.

AU - Tsiamis, George

AU - Arensburger, Peter

AU - Rio, Rita V M

AU - Macdonald, Sandy J.

AU - Panji, Sumir

AU - Kruger, Adele F.

AU - Benkahla, Alia

AU - Balyeidhusa, Apollo Simon Peter

AU - Msangi, Atway R.

AU - Okoro, Chinyere K.

AU - Stephens, Dawn

AU - Stanley, Eleanor J.

AU - Mpondo, Feziwe

AU - Wamwiri, Florence N.

AU - Mramba, Furaha

AU - Siwo, Geoffrey H.

AU - Githinji, George

AU - Harkins, Gordon William

AU - Murilla, Grace Adira

AU - Lehväslaiho, Heikki

AU - Malele, Imna I.

AU - Auma, Joanna Eseri

AU - Kinyua, Johnson K.

AU - Ouma, Johnson O.

AU - Okedi, Loyce M A

AU - Manga, Lucien

AU - Aslett, Martin A.

AU - Koffi, Mathurin

AU - Gaunt, Michael W.

AU - Makgamathe, Mmule

AU - Mulder, Nicola Jane

AU - Manangwa, Oliver

AU - Abila, Patrick P.

AU - Wincker, Patrick

AU - Gregory, Richard I.

AU - Bateta, Rosemary

AU - Sakate, Ryuichi

AU - Ommeh, Sheila

AU - Lehane, Stella M.

AU - Imanishi, Tadashi

AU - Osamor, Victor Chukwudi

AU - Kawahara, Yoshihiro

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The public release and future updates of the genome sequence and associated information are hosted at VectorBase (www.vectorbase.org). The genome sequence can also be found at GenBank under the accession no. CCAG010000000. The Glossina morsitans genome project was funded by the Wellcome Trust (grants 085775/Z/08/Z and 098051) and World Health Organization (WHO) Special Programme for Research and Training in Tropical Diseases (TDR) (project no. A90088) and the Ambrose Monell Foundation. Authors also acknowledge support by the Food and Agriculture Organization/International Atomic Energy Agency Coordinated Research Program "Improving SIT for Tsetse Flies through Research on their Symbionts," the European Union Cooperation in Science and Technology (COST) Action FA0701 "Arthropod Symbiosis: From Fundamental Studies to Pest and Disease Management," and a grant-in-aid for Scientific Research on Priority Areas "Comprehensive Genomics" from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (to M. H.). BAC libraries were generated through National Institute of Allergy and Infectious Diseases resources, and sequencing was supported by RIKEN Japan. We thank the staff in the library construction, sequence production, and informatics support groups at the Wellcome Trust Sanger Institute.

PY - 2014/4/24

Y1 - 2014/4/24

N2 - Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.

AB - Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.

UR - http://hdl.handle.net/10754/563509

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077534

UR - http://www.scopus.com/inward/record.url?scp=84899560044&partnerID=8YFLogxK

U2 - 10.1126/science.1249656

DO - 10.1126/science.1249656

M3 - Article

C2 - 24763584

SN - 0036-8075

VL - 344

SP - 380

EP - 386

JO - Science

JF - Science

IS - 6182

ER -

Genome sequence of the tsetse fly (Glossina morsitans ): Vector of African trypanosomiasis

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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