With antimicrobial resistance on the rise, the discovery of new compounds with novel structural scaffolds exhibiting antimicrobial properties has become an important area of research. Such compounds can serve as starting points for the development of new antimicrobials. In this report, we present the draft genome sequence of the Zooshikella ganghwensis strain VG4, isolated from Red Sea sediments, that produces metabolites with antimicrobial properties. A genomic analysis reveals that it carries at least five gene clusters that have the potential to direct biosynthesis of bioactive secondary metabolites such as polyketides and nonribosomal peptides. By using in-silico approaches, we predict the structure of these metabolites.
Bibliographical noteFunding Information:
The research reported in this publication was supported by funding from the King Abdullah University of Science and Technology (KAUST), KAUST Office of Sponsored Research (OSR) under awards number URF/1/2302 and No URF/1/1976-02, and KAUST Base Research Fund ( BAS/1/1606-01-01 ) and ( BAS/1/1061-01-01 ) to VBB and TL, respectively. We are thankful to the technical staff at the Bioscience core labs of KAUST for their assistance with genomic DNA isolation and sequencing.
© 2018 The Author
- Bioactive secondary metabolites
- Nonribosomal peptides
- Zooshikella ganghwensis genome
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology