Genome sequence analysis of Zooshikella ganghwensis strain VG4 and its potential for the synthesis of antimicrobial metabolites

Zahid ur Rehman; Intikhab Alam; Allan Anthony Kamau; Vladimir B. Bajic; Tor Ove Leiknes

doi:10.1016/j.btre.2018.e00278

Genome sequence analysis of Zooshikella ganghwensis strain VG4 and its potential for the synthesis of antimicrobial metabolites

Zahid ur Rehman^*, Intikhab Alam, Allan Anthony Kamau, Vladimir B. Bajic, Tor Ove Leiknes

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

With antimicrobial resistance on the rise, the discovery of new compounds with novel structural scaffolds exhibiting antimicrobial properties has become an important area of research. Such compounds can serve as starting points for the development of new antimicrobials. In this report, we present the draft genome sequence of the Zooshikella ganghwensis strain VG4, isolated from Red Sea sediments, that produces metabolites with antimicrobial properties. A genomic analysis reveals that it carries at least five gene clusters that have the potential to direct biosynthesis of bioactive secondary metabolites such as polyketides and nonribosomal peptides. By using in-silico approaches, we predict the structure of these metabolites.

Original language	English (US)
Article number	e00278
Journal	Biotechnology Reports
Volume	19
DOIs	https://doi.org/10.1016/j.btre.2018.e00278
State	Published - Sep 2018

Bibliographical note

Funding Information:
The research reported in this publication was supported by funding from the King Abdullah University of Science and Technology (KAUST), KAUST Office of Sponsored Research (OSR) under awards number URF/1/2302 and No URF/1/1976-02, and KAUST Base Research Fund ( BAS/1/1606-01-01 ) and ( BAS/1/1061-01-01 ) to VBB and TL, respectively. We are thankful to the technical staff at the Bioscience core labs of KAUST for their assistance with genomic DNA isolation and sequencing.

Publisher Copyright:
© 2018 The Author

Keywords

Bioactive secondary metabolites
NRP
Nonribosomal peptides
PK
Polyketides
Zooshikella ganghwensis genome

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Biotechnology

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10.1016/j.btre.2018.e00278

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title = "Genome sequence analysis of Zooshikella ganghwensis strain VG4 and its potential for the synthesis of antimicrobial metabolites",

abstract = "With antimicrobial resistance on the rise, the discovery of new compounds with novel structural scaffolds exhibiting antimicrobial properties has become an important area of research. Such compounds can serve as starting points for the development of new antimicrobials. In this report, we present the draft genome sequence of the Zooshikella ganghwensis strain VG4, isolated from Red Sea sediments, that produces metabolites with antimicrobial properties. A genomic analysis reveals that it carries at least five gene clusters that have the potential to direct biosynthesis of bioactive secondary metabolites such as polyketides and nonribosomal peptides. By using in-silico approaches, we predict the structure of these metabolites.",

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note = "Funding Information: The research reported in this publication was supported by funding from the King Abdullah University of Science and Technology (KAUST), KAUST Office of Sponsored Research (OSR) under awards number URF/1/2302 and No URF/1/1976-02, and KAUST Base Research Fund ( BAS/1/1606-01-01 ) and ( BAS/1/1061-01-01 ) to VBB and TL, respectively. We are thankful to the technical staff at the Bioscience core labs of KAUST for their assistance with genomic DNA isolation and sequencing. Publisher Copyright: {\textcopyright} 2018 The Author",

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AU - Kamau, Allan Anthony

AU - Bajic, Vladimir B.

AU - Leiknes, Tor Ove

N1 - Funding Information: The research reported in this publication was supported by funding from the King Abdullah University of Science and Technology (KAUST), KAUST Office of Sponsored Research (OSR) under awards number URF/1/2302 and No URF/1/1976-02, and KAUST Base Research Fund ( BAS/1/1606-01-01 ) and ( BAS/1/1061-01-01 ) to VBB and TL, respectively. We are thankful to the technical staff at the Bioscience core labs of KAUST for their assistance with genomic DNA isolation and sequencing. Publisher Copyright: © 2018 The Author

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N2 - With antimicrobial resistance on the rise, the discovery of new compounds with novel structural scaffolds exhibiting antimicrobial properties has become an important area of research. Such compounds can serve as starting points for the development of new antimicrobials. In this report, we present the draft genome sequence of the Zooshikella ganghwensis strain VG4, isolated from Red Sea sediments, that produces metabolites with antimicrobial properties. A genomic analysis reveals that it carries at least five gene clusters that have the potential to direct biosynthesis of bioactive secondary metabolites such as polyketides and nonribosomal peptides. By using in-silico approaches, we predict the structure of these metabolites.

AB - With antimicrobial resistance on the rise, the discovery of new compounds with novel structural scaffolds exhibiting antimicrobial properties has become an important area of research. Such compounds can serve as starting points for the development of new antimicrobials. In this report, we present the draft genome sequence of the Zooshikella ganghwensis strain VG4, isolated from Red Sea sediments, that produces metabolites with antimicrobial properties. A genomic analysis reveals that it carries at least five gene clusters that have the potential to direct biosynthesis of bioactive secondary metabolites such as polyketides and nonribosomal peptides. By using in-silico approaches, we predict the structure of these metabolites.

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Genome sequence analysis of Zooshikella ganghwensis strain VG4 and its potential for the synthesis of antimicrobial metabolites

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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