Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species

Hifzur Rahman Ansari; Thomas J. Templeton; Amit Subudhi; Abhinay Ramaprasad; Jianxia Tang; Feng Lu; Raeece Naeem; Yasmeen Hashish; Mary C. Oguike; Ernest Diez Benavente; Taane G. Clark; Colin J. Sutherland; John W. Barnwell; Richard Culleton; Jun Cao; Arnab Pain

doi:10.1016/j.ijpara.2016.05.009

Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species

Hifzur Rahman Ansari, Thomas J. Templeton, Amit Subudhi, Abhinay Ramaprasad, Jianxia Tang, Feng Lu, Raeece Naeem, Yasmeen Hashish, Mary C. Oguike, Ernest Diez Benavente, Taane G. Clark, Colin J. Sutherland, John W. Barnwell, Richard Culleton, Jun Cao, Arnab Pain

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Malaria in humans is caused by six species of Plasmodium parasites, of which the nuclear genome sequences for the two Plasmodium ovale spp., P. ovale curtisi and P. ovale wallikeri, and Plasmodium malariae have not yet been analyzed. Here we present an analysis of the nuclear genome sequences of these three parasites, and describe gene family expansions therein. Plasmodium ovale curtisi and P. ovale wallikeri are genetically distinct but morphologically indistinguishable and have sympatric ranges through the tropics of Africa, Asia and Oceania. Both P. ovale spp. show expansion of the surfin variant gene family, and an amplification of the Plasmodium interspersed repeat (pir) superfamily which results in an approximately 30% increase in genome size. For comparison, we have also analyzed the draft nuclear genome of P. malariae, a malaria parasite causing mild malaria symptoms with a quartan life cycle, long-term chronic infections, and wide geographic distribution. Plasmodium malariae shows only a moderate level of expansion of pir genes, and unique expansions of a highly diverged transmembrane protein family with over 550 members and the gamete P25/27 gene family. The observed diversity in the P. ovale wallikeri and P. ovale curtisi surface antigens, combined with their phylogenetic separation, supports consideration that the two parasites be given species status.

Original language	English (US)
Pages (from-to)	685-696
Number of pages	12
Journal	International Journal for Parasitology
Volume	46
Issue number	11
DOIs	https://doi.org/10.1016/j.ijpara.2016.05.009
State	Published - Jul 5 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: TJT was supported by a visiting professorship to the Institute of Tropical Medicine, Nagasaki University, Japan. JC was supported by grants from the National Natural Science Foundation of China (No. 81271870) and the National Natural Science Foundation of Jiangsu Province, China (No. BK20150001). AP is supported by faculty baseline funding from the King Abdullah University of Science and Technology (KAUST), Saudi Arabia and the Global Institute for Collaborative Research and Education (GI-CoRE) at the Center for Disease Control, Hokkaido University, Japan. RC is supported by Japanese Society of Parasitology (JSPS), Japan Grant-in-Aid for Scientific Research Nos. 24255009, 25870525 and 16K21233. MCO, EDB, TGC and CJS are supported by UK Medical Research Council Project Grant MR/L008661/1 to CJS. The authors thank the staff of the Bioscience Core Laboratory in KAUST for sequencing the DNA libraries. Osamu Kaneko is thanked for discussions and critical reading of the manuscript.

ASJC Scopus subject areas

Infectious Diseases
Parasitology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijpara.2016.05.009

https://repository.kaust.edu.sa/bitstream/10754/617088/1/1-s2.0-S0020751916301357-main.pdf

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Ansari, H. R., Templeton, T. J., Subudhi, A., Ramaprasad, A., Tang, J., Lu, F., Naeem, R., Hashish, Y., Oguike, M. C., Benavente, E. D., Clark, T. G., Sutherland, C. J., Barnwell, J. W., Culleton, R., Cao, J., & Pain, A. (2016). Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species. International Journal for Parasitology, 46(11), 685-696. https://doi.org/10.1016/j.ijpara.2016.05.009

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title = "Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species",

abstract = "Malaria in humans is caused by six species of Plasmodium parasites, of which the nuclear genome sequences for the two Plasmodium ovale spp., P. ovale curtisi and P. ovale wallikeri, and Plasmodium malariae have not yet been analyzed. Here we present an analysis of the nuclear genome sequences of these three parasites, and describe gene family expansions therein. Plasmodium ovale curtisi and P. ovale wallikeri are genetically distinct but morphologically indistinguishable and have sympatric ranges through the tropics of Africa, Asia and Oceania. Both P. ovale spp. show expansion of the surfin variant gene family, and an amplification of the Plasmodium interspersed repeat (pir) superfamily which results in an approximately 30% increase in genome size. For comparison, we have also analyzed the draft nuclear genome of P. malariae, a malaria parasite causing mild malaria symptoms with a quartan life cycle, long-term chronic infections, and wide geographic distribution. Plasmodium malariae shows only a moderate level of expansion of pir genes, and unique expansions of a highly diverged transmembrane protein family with over 550 members and the gamete P25/27 gene family. The observed diversity in the P. ovale wallikeri and P. ovale curtisi surface antigens, combined with their phylogenetic separation, supports consideration that the two parasites be given species status.",

author = "Ansari, {Hifzur Rahman} and Templeton, {Thomas J.} and Amit Subudhi and Abhinay Ramaprasad and Jianxia Tang and Feng Lu and Raeece Naeem and Yasmeen Hashish and Oguike, {Mary C.} and Benavente, {Ernest Diez} and Clark, {Taane G.} and Sutherland, {Colin J.} and Barnwell, {John W.} and Richard Culleton and Jun Cao and Arnab Pain",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: TJT was supported by a visiting professorship to the Institute of Tropical Medicine, Nagasaki University, Japan. JC was supported by grants from the National Natural Science Foundation of China (No. 81271870) and the National Natural Science Foundation of Jiangsu Province, China (No. BK20150001). AP is supported by faculty baseline funding from the King Abdullah University of Science and Technology (KAUST), Saudi Arabia and the Global Institute for Collaborative Research and Education (GI-CoRE) at the Center for Disease Control, Hokkaido University, Japan. RC is supported by Japanese Society of Parasitology (JSPS), Japan Grant-in-Aid for Scientific Research Nos. 24255009, 25870525 and 16K21233. MCO, EDB, TGC and CJS are supported by UK Medical Research Council Project Grant MR/L008661/1 to CJS. The authors thank the staff of the Bioscience Core Laboratory in KAUST for sequencing the DNA libraries. Osamu Kaneko is thanked for discussions and critical reading of the manuscript.",

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doi = "10.1016/j.ijpara.2016.05.009",

language = "English (US)",

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Ansari, HR, Templeton, TJ, Subudhi, A, Ramaprasad, A, Tang, J, Lu, F, Naeem, R, Hashish, Y, Oguike, MC, Benavente, ED, Clark, TG, Sutherland, CJ, Barnwell, JW, Culleton, R, Cao, J & Pain, A 2016, 'Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species', International Journal for Parasitology, vol. 46, no. 11, pp. 685-696. https://doi.org/10.1016/j.ijpara.2016.05.009

Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species. / Ansari, Hifzur Rahman; Templeton, Thomas J.; Subudhi, Amit et al.
In: International Journal for Parasitology, Vol. 46, No. 11, 05.07.2016, p. 685-696.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species

AU - Ansari, Hifzur Rahman

AU - Templeton, Thomas J.

AU - Subudhi, Amit

AU - Ramaprasad, Abhinay

AU - Tang, Jianxia

AU - Lu, Feng

AU - Naeem, Raeece

AU - Hashish, Yasmeen

AU - Oguike, Mary C.

AU - Benavente, Ernest Diez

AU - Clark, Taane G.

AU - Sutherland, Colin J.

AU - Barnwell, John W.

AU - Culleton, Richard

AU - Cao, Jun

AU - Pain, Arnab

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: TJT was supported by a visiting professorship to the Institute of Tropical Medicine, Nagasaki University, Japan. JC was supported by grants from the National Natural Science Foundation of China (No. 81271870) and the National Natural Science Foundation of Jiangsu Province, China (No. BK20150001). AP is supported by faculty baseline funding from the King Abdullah University of Science and Technology (KAUST), Saudi Arabia and the Global Institute for Collaborative Research and Education (GI-CoRE) at the Center for Disease Control, Hokkaido University, Japan. RC is supported by Japanese Society of Parasitology (JSPS), Japan Grant-in-Aid for Scientific Research Nos. 24255009, 25870525 and 16K21233. MCO, EDB, TGC and CJS are supported by UK Medical Research Council Project Grant MR/L008661/1 to CJS. The authors thank the staff of the Bioscience Core Laboratory in KAUST for sequencing the DNA libraries. Osamu Kaneko is thanked for discussions and critical reading of the manuscript.

PY - 2016/7/5

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N2 - Malaria in humans is caused by six species of Plasmodium parasites, of which the nuclear genome sequences for the two Plasmodium ovale spp., P. ovale curtisi and P. ovale wallikeri, and Plasmodium malariae have not yet been analyzed. Here we present an analysis of the nuclear genome sequences of these three parasites, and describe gene family expansions therein. Plasmodium ovale curtisi and P. ovale wallikeri are genetically distinct but morphologically indistinguishable and have sympatric ranges through the tropics of Africa, Asia and Oceania. Both P. ovale spp. show expansion of the surfin variant gene family, and an amplification of the Plasmodium interspersed repeat (pir) superfamily which results in an approximately 30% increase in genome size. For comparison, we have also analyzed the draft nuclear genome of P. malariae, a malaria parasite causing mild malaria symptoms with a quartan life cycle, long-term chronic infections, and wide geographic distribution. Plasmodium malariae shows only a moderate level of expansion of pir genes, and unique expansions of a highly diverged transmembrane protein family with over 550 members and the gamete P25/27 gene family. The observed diversity in the P. ovale wallikeri and P. ovale curtisi surface antigens, combined with their phylogenetic separation, supports consideration that the two parasites be given species status.

AB - Malaria in humans is caused by six species of Plasmodium parasites, of which the nuclear genome sequences for the two Plasmodium ovale spp., P. ovale curtisi and P. ovale wallikeri, and Plasmodium malariae have not yet been analyzed. Here we present an analysis of the nuclear genome sequences of these three parasites, and describe gene family expansions therein. Plasmodium ovale curtisi and P. ovale wallikeri are genetically distinct but morphologically indistinguishable and have sympatric ranges through the tropics of Africa, Asia and Oceania. Both P. ovale spp. show expansion of the surfin variant gene family, and an amplification of the Plasmodium interspersed repeat (pir) superfamily which results in an approximately 30% increase in genome size. For comparison, we have also analyzed the draft nuclear genome of P. malariae, a malaria parasite causing mild malaria symptoms with a quartan life cycle, long-term chronic infections, and wide geographic distribution. Plasmodium malariae shows only a moderate level of expansion of pir genes, and unique expansions of a highly diverged transmembrane protein family with over 550 members and the gamete P25/27 gene family. The observed diversity in the P. ovale wallikeri and P. ovale curtisi surface antigens, combined with their phylogenetic separation, supports consideration that the two parasites be given species status.

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UR - http://linkinghub.elsevier.com/retrieve/pii/S0020751916301357

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U2 - 10.1016/j.ijpara.2016.05.009

DO - 10.1016/j.ijpara.2016.05.009

M3 - Article

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SN - 0020-7519

VL - 46

SP - 685

EP - 696

JO - International Journal for Parasitology

JF - International Journal for Parasitology

IS - 11

ER -

Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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