Generation of tunable and pulsatile concentration gradients via microfluidic network

Bingpu Zhou; Wei Xu; Cong Wang; Yeungyeung Chau; Xiping Zeng; Xixiang Zhang; Rong Shen; Weijia Wen

doi:10.1007/s10404-014-1432-9

Generation of tunable and pulsatile concentration gradients via microfluidic network

Bingpu Zhou, Wei Xu, Cong Wang, Yeungyeung Chau, Xiping Zeng, Xixiang Zhang, Rong Shen, Weijia Wen

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We demonstrate a compact Polydimethylsiloxane microfluidic chip which can quickly generate ten different chemical concentrations simultaneously. The concentration magnitude of each branch can be flexibly regulated based on the flow rate ratios of the two injecting streams. The temporal/pulsatile concentration gradients are achieved by integrating on-chip pneumatic actuated valves controlled by the external signals. The temporal concentration gradients can also be tuned precisely by varying applied frequency and duty cycle of the trigger signal. It is believed that such microdevice will be potentially used for some application areas of producing stable chemical gradients as well as allowing fast, pulsatile gradient transformation in seconds.

Original language	English (US)
Pages (from-to)	175-184
Number of pages	10
Journal	Microfluidics and Nanofluidics
Volume	18
Issue number	2
DOIs	https://doi.org/10.1007/s10404-014-1432-9
State	Published - Jun 4 2014

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): SA-C0040/UK-C0016
Acknowledgements: We would like to thank Prof. Andrew W. O. Poon's research group, of Department of Electronic and Computer Engineering in HKUST, for their assistance in COMSOL Multiphysics simulations. This publication is based on work partially supported by Award No. SA-C0040/UK-C0016, made by King Abdullah University of Science and Technology (KAUST), Hong Kong RGC Grants HKUST 604710 and 605411, and National Natural Science Foundation of China (Grant No. 11290165). The work is also partially supported by the Nanoscience and Nanotechnology Program at HKUST.

ASJC Scopus subject areas

Materials Chemistry
Electronic, Optical and Magnetic Materials
Condensed Matter Physics

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10.1007/s10404-014-1432-9

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title = "Generation of tunable and pulsatile concentration gradients via microfluidic network",

abstract = "We demonstrate a compact Polydimethylsiloxane microfluidic chip which can quickly generate ten different chemical concentrations simultaneously. The concentration magnitude of each branch can be flexibly regulated based on the flow rate ratios of the two injecting streams. The temporal/pulsatile concentration gradients are achieved by integrating on-chip pneumatic actuated valves controlled by the external signals. The temporal concentration gradients can also be tuned precisely by varying applied frequency and duty cycle of the trigger signal. It is believed that such microdevice will be potentially used for some application areas of producing stable chemical gradients as well as allowing fast, pulsatile gradient transformation in seconds.",

author = "Bingpu Zhou and Wei Xu and Cong Wang and Yeungyeung Chau and Xiping Zeng and Xixiang Zhang and Rong Shen and Weijia Wen",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): SA-C0040/UK-C0016 Acknowledgements: We would like to thank Prof. Andrew W. O. Poon's research group, of Department of Electronic and Computer Engineering in HKUST, for their assistance in COMSOL Multiphysics simulations. This publication is based on work partially supported by Award No. SA-C0040/UK-C0016, made by King Abdullah University of Science and Technology (KAUST), Hong Kong RGC Grants HKUST 604710 and 605411, and National Natural Science Foundation of China (Grant No. 11290165). The work is also partially supported by the Nanoscience and Nanotechnology Program at HKUST.",

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doi = "10.1007/s10404-014-1432-9",

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AU - Zhou, Bingpu

AU - Xu, Wei

AU - Wang, Cong

AU - Chau, Yeungyeung

AU - Zeng, Xiping

AU - Zhang, Xixiang

AU - Shen, Rong

AU - Wen, Weijia

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): SA-C0040/UK-C0016 Acknowledgements: We would like to thank Prof. Andrew W. O. Poon's research group, of Department of Electronic and Computer Engineering in HKUST, for their assistance in COMSOL Multiphysics simulations. This publication is based on work partially supported by Award No. SA-C0040/UK-C0016, made by King Abdullah University of Science and Technology (KAUST), Hong Kong RGC Grants HKUST 604710 and 605411, and National Natural Science Foundation of China (Grant No. 11290165). The work is also partially supported by the Nanoscience and Nanotechnology Program at HKUST.

PY - 2014/6/4

Y1 - 2014/6/4

N2 - We demonstrate a compact Polydimethylsiloxane microfluidic chip which can quickly generate ten different chemical concentrations simultaneously. The concentration magnitude of each branch can be flexibly regulated based on the flow rate ratios of the two injecting streams. The temporal/pulsatile concentration gradients are achieved by integrating on-chip pneumatic actuated valves controlled by the external signals. The temporal concentration gradients can also be tuned precisely by varying applied frequency and duty cycle of the trigger signal. It is believed that such microdevice will be potentially used for some application areas of producing stable chemical gradients as well as allowing fast, pulsatile gradient transformation in seconds.

AB - We demonstrate a compact Polydimethylsiloxane microfluidic chip which can quickly generate ten different chemical concentrations simultaneously. The concentration magnitude of each branch can be flexibly regulated based on the flow rate ratios of the two injecting streams. The temporal/pulsatile concentration gradients are achieved by integrating on-chip pneumatic actuated valves controlled by the external signals. The temporal concentration gradients can also be tuned precisely by varying applied frequency and duty cycle of the trigger signal. It is believed that such microdevice will be potentially used for some application areas of producing stable chemical gradients as well as allowing fast, pulsatile gradient transformation in seconds.

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ER -

Generation of tunable and pulsatile concentration gradients via microfluidic network

Abstract

Bibliographical note

ASJC Scopus subject areas

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