Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos

Lise Zakin, Bruno Reversade, Bérangère Virlon, Christophe Rusniok, Philippe Glaser, Jean Marc Elalouf, Philippe Brûlet

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2-/- 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization of the embryo before gastrulation.
Original languageEnglish (US)
Pages (from-to)14388-14393
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number26
StatePublished - Dec 19 2000
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-02-15

ASJC Scopus subject areas

  • General


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