Gastroretentive drug delivery systems for therapeutic management of peptic ulcer

Tarun Garg, Animesh Kumar, Goutam Rath, Amit K. Goyal

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

A peptic ulcer, stomach ulcer, or gastric ulcer, also known as peptic ulcer disease (PUD), is a very common chronic disorder of the stomach which is mainly caused by damage or impairment of the stomach lining. Various factors such as pepsin, gastric acid, H. pylori, NSAIDs, prostaglandins, mucus, bicarbonate, and blood flow to mucosa play an important role in causing peptic ulcers. In this review article, our main focus is on some important gastroretentive drug delivery systems (GRDDS) (floating, bioadhesive, high density, swellable, raft forming, superporous hydrogel, and magnetic systems) which will be helpful in gastroretention of different dosage forms for treatment of peptic ulcer. GRDDS provides a mean for controlled release of compounds that are absorbed by active transport in the upper intestine. It also enables controlled delivery for paracellularly absorbed drugs without a decrease in bioavailability. The above approaches are specific for targeting and leading to a marked improvement in the quality of life for a large number of patients. In the future, it is expected that they will become of growing significance, finally leading to improved efficiencies of various types of pharmacotherapies.
Original languageEnglish (US)
Pages (from-to)531-557
Number of pages27
JournalCritical Reviews in Therapeutic Drug Carrier Systems
Volume31
Issue number6
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Generated from Scopus record by KAUST IRTS on 2023-10-12

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