Folding Up of Gold Nanoparticle Strings into Plasmonic Vesicles for Enhanced Photoacoustic Imaging

Yijing Liu, Jie He, Kuikun Yang, Chenglin Yi, Yi Liu, Liming Nie, Niveen M. Khashab, Xiaoyuan Chen, Zhihong Nie

Research output: Contribution to journalArticlepeer-review

164 Scopus citations


The stepwise self-assembly of hollow plasmonic vesicles with vesicular membranes containing strings of gold nanoparticles (NPs) is reported. The formation of chain vesicles can be controlled by tuning the density of the polymer ligands on the surface of the gold NPs. The strong absorption of the chain vesicles in the near-infrared (NIR) region leads to a much higher efficiency in photoacoustic (PA) imaging than for non-chain vesicles. The chain vesicles were further employed for the encapsulation of drugs and the NIR light triggered release of payloads. This work not only offers a new platform for controlling the hierarchical self-assembly of NPs, but also demonstrates that the physical properties of the materials can be tailored by controlling the spatial arrangement of NPs within assemblies to achieve a better performance in biomedical applications.
Original languageEnglish (US)
Pages (from-to)15809-15812
Number of pages4
JournalAngewandte Chemie International Edition
Issue number52
StatePublished - Nov 11 2015

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was funded by a National Science Foundation (NSF) CAREER award (DMR-1255377), the ACS Petroleum Research Fund (PRF 53461-DNI7), a 3M non-tenured faculty award, and the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health. We acknowledge support by the Maryland NanoCenter and its NispLab.


Dive into the research topics of 'Folding Up of Gold Nanoparticle Strings into Plasmonic Vesicles for Enhanced Photoacoustic Imaging'. Together they form a unique fingerprint.

Cite this