First heterogeneous ligand- and salt-free larock indole Synthesis

Nelly Batail, Anissa Bendjeriou, Thierry Lomberget, Roland Barrett, Véronique Dufaud*, Laurent Djakovitch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

A new ligand- and salt-free procedure using heterogeneous palladium catalysts for the Larock indole and benzofuran synthesis is reported. After optimisation of the reaction conditions, good to high isolated yields have been achieved for a variety of structures. Recycling studies have shown that the palladium catalysts can be readily recovered and reused. Reactions and recovery of the palladium catalysts can be carried out in the presence of air, without any particular precaution.

Original languageEnglish (US)
Pages (from-to)2055-2062
Number of pages8
JournalAdvanced Synthesis and Catalysis
Volume351
Issue number13
DOIs
StatePublished - Sep 2009
Externally publishedYes

Keywords

  • Benzofurans
  • Heterogeneous catalysis
  • Indoles
  • Larock synthesis
  • Palladium catalysts

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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