First heterogeneous ligand- and salt-free larock indole Synthesis

Nelly Batail; Anissa Bendjeriou; Thierry Lomberget; Roland Barrett; Véronique Dufaud; Laurent Djakovitch

doi:10.1002/adsc.200900386

First heterogeneous ligand- and salt-free larock indole Synthesis

Nelly Batail, Anissa Bendjeriou, Thierry Lomberget, Roland Barrett, Véronique Dufaud^*, Laurent Djakovitch

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

A new ligand- and salt-free procedure using heterogeneous palladium catalysts for the Larock indole and benzofuran synthesis is reported. After optimisation of the reaction conditions, good to high isolated yields have been achieved for a variety of structures. Recycling studies have shown that the palladium catalysts can be readily recovered and reused. Reactions and recovery of the palladium catalysts can be carried out in the presence of air, without any particular precaution.

Original language	English (US)
Pages (from-to)	2055-2062
Number of pages	8
Journal	Advanced Synthesis and Catalysis
Volume	351
Issue number	13
DOIs	https://doi.org/10.1002/adsc.200900386
State	Published - Sep 2009
Externally published	Yes

Keywords

Benzofurans
Heterogeneous catalysis
Indoles
Larock synthesis
Palladium catalysts

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1002/adsc.200900386

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AU - Batail, Nelly

AU - Bendjeriou, Anissa

AU - Lomberget, Thierry

AU - Barrett, Roland

AU - Dufaud, Véronique

AU - Djakovitch, Laurent

PY - 2009/9

Y1 - 2009/9

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AB - A new ligand- and salt-free procedure using heterogeneous palladium catalysts for the Larock indole and benzofuran synthesis is reported. After optimisation of the reaction conditions, good to high isolated yields have been achieved for a variety of structures. Recycling studies have shown that the palladium catalysts can be readily recovered and reused. Reactions and recovery of the palladium catalysts can be carried out in the presence of air, without any particular precaution.

KW - Benzofurans

KW - Heterogeneous catalysis

KW - Indoles

KW - Larock synthesis

KW - Palladium catalysts

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ER -

First heterogeneous ligand- and salt-free larock indole Synthesis

Abstract

Keywords

ASJC Scopus subject areas

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