Extracellular modulation of the hedgehog, Wnt and TGF-β signalling pathways during embryonic development

Javier Capdevila, Juan Carlos Izpisua Belmonte*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Localized embryonic expression of members of the Hedgehog, Wnt and TGF-β families of secreted factors has been shown to organize pattern and provide positional information in many developing systems. Recently, several extracellular factors have been described that act either as facilitators or inhibitors of the activities of those secreted proteins. The variety of molecular strategies involved in the extracellular modulation of signalling activities in the embryo underscores the importance of maintaining a tight spatial and temporal control of the activities of organizing centers during development.

Original languageEnglish (US)
Pages (from-to)427-433
Number of pages7
JournalCurrent Opinion in Genetics and Development
Issue number4
StatePublished - Aug 4 1999

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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