Expression quantitative trait loci in long non-coding RNA ZNRD1-AS1 influence cervical cancer development

Lanwei Guo; Juan Wen; Jing Han; Jie Jiang; Shuanghua Xie; Xiaoshuang Feng; Baojun Wei; Juncheng Dai; Kai Zhang; Jun Qi; Hongxia Ma; Jufang Shi; Jiansong Ren; Yue Zhang; Min Dai; Zhibin Hu; Ni Li

Expression quantitative trait loci in long non-coding RNA ZNRD1-AS1 influence cervical cancer development

Lanwei Guo, Juan Wen, Jing Han, Jie Jiang, Shuanghua Xie, Xiaoshuang Feng, Baojun Wei, Juncheng Dai, Kai Zhang, Jun Qi, Hongxia Ma, Jufang Shi, Jiansong Ren, Yue Zhang, Min Dai, Zhibin Hu, Ni Li

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Zinc ribbon domain containing 1 (ZNRD1) may play integral roles in immune response against HPV infection and cervical cancer. Its antisense transcript, ZNRD1-AS1, is an important regulator of ZNRD1. By bioinformatics analyses, we identified that several single nucleotide polymorphisms (SNPs) in ZNRD1-AS1 may be expression quantitative trait loci (eQTLs) for ZNRD1. So we hypothesized that these eQTLs SNPs in ZNRD1-AS1 may influence the susceptibility of cervical cancer through influencing ZNRD1 expression. We designed a population-based case-control study containing 1486 cervical cancer patients and 1536 controls to test the associations of three ZNRD1 eQTLs SNPs (rs3757328, rs6940552 and rs9261204) in ZNRD1-AS1 with the risk of cervical cancer. Logistic regression analyses in additive genetic model showed that all the three eQTLs SNPs decreased the risk of cervical cancer. Compared with those carrying "0" variant allele, subjects carrying "1-6" variant alleles had a 20% decreased risk of cervical cancer. Moreover, the haplotype containing variant alleles of these three SNPs significantly decreased the risk of cervical cancer when compared with the most frequent haplotype. In conclusion, ZNRD1 eQTLs SNPs in ZNRD1-AS1 could have a predisposition for the development of cervical cancer.

Original language	English (US)
Pages (from-to)	2301-2307
Number of pages	7
Journal	American Journal of Cancer Research
Volume	5
Issue number	7
State	Published - Jan 1 2015
Externally published	Yes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-09-21

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Expression quantitative trait loci in long non-coding RNA ZNRD1-AS1 influence cervical cancer development",

abstract = "Zinc ribbon domain containing 1 (ZNRD1) may play integral roles in immune response against HPV infection and cervical cancer. Its antisense transcript, ZNRD1-AS1, is an important regulator of ZNRD1. By bioinformatics analyses, we identified that several single nucleotide polymorphisms (SNPs) in ZNRD1-AS1 may be expression quantitative trait loci (eQTLs) for ZNRD1. So we hypothesized that these eQTLs SNPs in ZNRD1-AS1 may influence the susceptibility of cervical cancer through influencing ZNRD1 expression. We designed a population-based case-control study containing 1486 cervical cancer patients and 1536 controls to test the associations of three ZNRD1 eQTLs SNPs (rs3757328, rs6940552 and rs9261204) in ZNRD1-AS1 with the risk of cervical cancer. Logistic regression analyses in additive genetic model showed that all the three eQTLs SNPs decreased the risk of cervical cancer. Compared with those carrying {"}0{"} variant allele, subjects carrying {"}1-6{"} variant alleles had a 20% decreased risk of cervical cancer. Moreover, the haplotype containing variant alleles of these three SNPs significantly decreased the risk of cervical cancer when compared with the most frequent haplotype. In conclusion, ZNRD1 eQTLs SNPs in ZNRD1-AS1 could have a predisposition for the development of cervical cancer.",

author = "Lanwei Guo and Juan Wen and Jing Han and Jie Jiang and Shuanghua Xie and Xiaoshuang Feng and Baojun Wei and Juncheng Dai and Kai Zhang and Jun Qi and Hongxia Ma and Jufang Shi and Jiansong Ren and Yue Zhang and Min Dai and Zhibin Hu and Ni Li",

note = "Generated from Scopus record by KAUST IRTS on 2023-09-21",

year = "2015",

month = jan,

day = "1",

language = "English (US)",

volume = "5",

pages = "2301--2307",

journal = "American Journal of Cancer Research",

issn = "2156-6976",

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TY - JOUR

T1 - Expression quantitative trait loci in long non-coding RNA ZNRD1-AS1 influence cervical cancer development

AU - Guo, Lanwei

AU - Wen, Juan

AU - Han, Jing

AU - Jiang, Jie

AU - Xie, Shuanghua

AU - Feng, Xiaoshuang

AU - Wei, Baojun

AU - Dai, Juncheng

AU - Zhang, Kai

AU - Qi, Jun

AU - Ma, Hongxia

AU - Shi, Jufang

AU - Ren, Jiansong

AU - Zhang, Yue

AU - Dai, Min

AU - Hu, Zhibin

AU - Li, Ni

N1 - Generated from Scopus record by KAUST IRTS on 2023-09-21

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Zinc ribbon domain containing 1 (ZNRD1) may play integral roles in immune response against HPV infection and cervical cancer. Its antisense transcript, ZNRD1-AS1, is an important regulator of ZNRD1. By bioinformatics analyses, we identified that several single nucleotide polymorphisms (SNPs) in ZNRD1-AS1 may be expression quantitative trait loci (eQTLs) for ZNRD1. So we hypothesized that these eQTLs SNPs in ZNRD1-AS1 may influence the susceptibility of cervical cancer through influencing ZNRD1 expression. We designed a population-based case-control study containing 1486 cervical cancer patients and 1536 controls to test the associations of three ZNRD1 eQTLs SNPs (rs3757328, rs6940552 and rs9261204) in ZNRD1-AS1 with the risk of cervical cancer. Logistic regression analyses in additive genetic model showed that all the three eQTLs SNPs decreased the risk of cervical cancer. Compared with those carrying "0" variant allele, subjects carrying "1-6" variant alleles had a 20% decreased risk of cervical cancer. Moreover, the haplotype containing variant alleles of these three SNPs significantly decreased the risk of cervical cancer when compared with the most frequent haplotype. In conclusion, ZNRD1 eQTLs SNPs in ZNRD1-AS1 could have a predisposition for the development of cervical cancer.

AB - Zinc ribbon domain containing 1 (ZNRD1) may play integral roles in immune response against HPV infection and cervical cancer. Its antisense transcript, ZNRD1-AS1, is an important regulator of ZNRD1. By bioinformatics analyses, we identified that several single nucleotide polymorphisms (SNPs) in ZNRD1-AS1 may be expression quantitative trait loci (eQTLs) for ZNRD1. So we hypothesized that these eQTLs SNPs in ZNRD1-AS1 may influence the susceptibility of cervical cancer through influencing ZNRD1 expression. We designed a population-based case-control study containing 1486 cervical cancer patients and 1536 controls to test the associations of three ZNRD1 eQTLs SNPs (rs3757328, rs6940552 and rs9261204) in ZNRD1-AS1 with the risk of cervical cancer. Logistic regression analyses in additive genetic model showed that all the three eQTLs SNPs decreased the risk of cervical cancer. Compared with those carrying "0" variant allele, subjects carrying "1-6" variant alleles had a 20% decreased risk of cervical cancer. Moreover, the haplotype containing variant alleles of these three SNPs significantly decreased the risk of cervical cancer when compared with the most frequent haplotype. In conclusion, ZNRD1 eQTLs SNPs in ZNRD1-AS1 could have a predisposition for the development of cervical cancer.

UR - http://www.scopus.com/inward/record.url?scp=85006219622&partnerID=8YFLogxK

M3 - Article

SN - 2156-6976

VL - 5

SP - 2301

EP - 2307

JO - American Journal of Cancer Research

JF - American Journal of Cancer Research

IS - 7

ER -

Expression quantitative trait loci in long non-coding RNA ZNRD1-AS1 influence cervical cancer development

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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