Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

J. C. Izpisúa-Belmonte; C. Tickle; P. Dollé; L. Wolpert; D. Duboule

doi:10.1038/350585a0

Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

J. C. Izpisúa-Belmonte, C. Tickle, P. Dollé, L. Wolpert, D. Duboule^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

363 Scopus citations

Abstract

The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.

Original language	English (US)
Pages (from-to)	585-589
Number of pages	5
Journal	NATURE
Volume	350
Issue number	6319
DOIs	https://doi.org/10.1038/350585a0
State	Published - 1991
Externally published	Yes

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abstract = "The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.",

author = "Izpis{\'u}a-Belmonte, {J. C.} and C. Tickle and P. Doll{\'e} and L. Wolpert and D. Duboule",

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AU - Izpisúa-Belmonte, J. C.

AU - Tickle, C.

AU - Dollé, P.

AU - Wolpert, L.

AU - Duboule, D.

PY - 1991

Y1 - 1991

N2 - The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.

AB - The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.

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U2 - 10.1038/350585a0

DO - 10.1038/350585a0

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Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

Abstract

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