Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

Juan Carlos Izpisua Belmonte, C. Tickle, P. Dollé, L. Wolpert, D. Duboule*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

316 Scopus citations


The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.

Original languageEnglish (US)
Pages (from-to)585-589
Number of pages5
Issue number6319
StatePublished - Jan 1 1991

ASJC Scopus subject areas

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