TY - JOUR
T1 - Expression of the chick vascular endothelial growth factor D gene during limb development
AU - Trelles, Ramón Díaz
AU - León, Joaquín Rodríguez
AU - Kawakami, Yasuhiko
AU - Simoes, Sofia
AU - Izpisua Belmonte, Juan Carlos
PY - 2002/7/30
Y1 - 2002/7/30
N2 - Vascular endothelial growth factor D (VEGF-D) is a member of the VEGF/PDGF superfamily that has been implicated in angiogenesis and lymphangiogenesis. We have isolated a chick cDNA that shows homology with VEGF-D (also known as FIGF, c-fos-induced growth factor) of other species. Here, we describe the expression pattern of cVegf-D in chick embryos. In the limb buds, cVegf-D shows a dynamic expression pattern that is restricted to the mesenchyme of the posterior region. cVegf-D expression is also detected in the ectoderm and mesenchyme of the head region, somites, notochord and pharyngeal arches. We also report on the capability of Sonic hedgehog and retinoic acid to regulate cVegf-D expression.
AB - Vascular endothelial growth factor D (VEGF-D) is a member of the VEGF/PDGF superfamily that has been implicated in angiogenesis and lymphangiogenesis. We have isolated a chick cDNA that shows homology with VEGF-D (also known as FIGF, c-fos-induced growth factor) of other species. Here, we describe the expression pattern of cVegf-D in chick embryos. In the limb buds, cVegf-D shows a dynamic expression pattern that is restricted to the mesenchyme of the posterior region. cVegf-D expression is also detected in the ectoderm and mesenchyme of the head region, somites, notochord and pharyngeal arches. We also report on the capability of Sonic hedgehog and retinoic acid to regulate cVegf-D expression.
UR - http://www.scopus.com/inward/record.url?scp=0036065570&partnerID=8YFLogxK
U2 - 10.1016/S0925-4773(02)00151-X
DO - 10.1016/S0925-4773(02)00151-X
M3 - Article
C2 - 12128233
AN - SCOPUS:0036065570
SN - 2667-291X
VL - 116
SP - 239
EP - 242
JO - Cells and Development
JF - Cells and Development
IS - 1-2
ER -