Exploring the Potential Molecular Mechanisms of Interactions between a Probiotic Consortium and Its Coral Host

Phillipe M. Rosado; Pedro M. Cardoso; João G. Rosado; Júnia Schultz; Ulisses Nunes da Rocha; Tina Keller-Costa; Raquel S. Peixoto

doi:10.1128/msystems.00921-22

Exploring the Potential Molecular Mechanisms of Interactions between a Probiotic Consortium and Its Coral Host

Phillipe M. Rosado, Pedro M. Cardoso, João G. Rosado, Júnia Schultz, Ulisses Nunes da Rocha, Tina Keller-Costa, Raquel S. Peixoto^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Beneficial microorganisms for corals (BMCs) have been demonstrated to be effective probiotics to alleviate bleaching and mitigate coral mortality in vivo. The selection of putative BMCs is traditionally performed manually, using an array of biochemical and molecular tests for putative BMC traits. We present a comprehensive genetic survey of BMC traits using a genome-based framework for the identification of alternative mechanisms that can be used for future in silico selection of BMC strains. We identify exclusive BMC traits associated with specific strains and propose new BMC mechanisms, such as the synthesis of glycine betaine and ectoines. Our roadmap facilitates the selection of BMC strains while increasing the array of genetic targets that can be included in the selection of putative BMC strains to be tested as coral probiotics.

Original language	English (US)
Journal	mSystems
Volume	8
Issue number	1
DOIs	https://doi.org/10.1128/msystems.00921-22
State	Published - Jan 2023

Bibliographical note

Funding Information:
This work was supported by grants FCC/1/1973-51-01, REI/1/4984-01, and BAS/1/ 1095-01-01 from King Abdullah University of Science and Technology (R.S.P.).

Publisher Copyright:
Copyright © 2023 Rosado et al.

Keywords

beneficial microorganisms for corals (BMCs)
BMCs
coral probiotics
genomes
holobiont
mechanisms
molecular interactions
probiotics
symbiosis

ASJC Scopus subject areas

Microbiology
Physiology
Biochemistry
Ecology, Evolution, Behavior and Systematics
Modeling and Simulation
Molecular Biology
Genetics
Computer Science Applications

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10.1128/msystems.00921-22

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title = "Exploring the Potential Molecular Mechanisms of Interactions between a Probiotic Consortium and Its Coral Host",

abstract = "Beneficial microorganisms for corals (BMCs) have been demonstrated to be effective probiotics to alleviate bleaching and mitigate coral mortality in vivo. The selection of putative BMCs is traditionally performed manually, using an array of biochemical and molecular tests for putative BMC traits. We present a comprehensive genetic survey of BMC traits using a genome-based framework for the identification of alternative mechanisms that can be used for future in silico selection of BMC strains. We identify exclusive BMC traits associated with specific strains and propose new BMC mechanisms, such as the synthesis of glycine betaine and ectoines. Our roadmap facilitates the selection of BMC strains while increasing the array of genetic targets that can be included in the selection of putative BMC strains to be tested as coral probiotics.",

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note = "Funding Information: This work was supported by grants FCC/1/1973-51-01, REI/1/4984-01, and BAS/1/ 1095-01-01 from King Abdullah University of Science and Technology (R.S.P.). Publisher Copyright: Copyright {\textcopyright} 2023 Rosado et al.",

year = "2023",

month = jan,

doi = "10.1128/msystems.00921-22",

language = "English (US)",

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AU - da Rocha, Ulisses Nunes

AU - Keller-Costa, Tina

AU - Peixoto, Raquel S.

N1 - Funding Information: This work was supported by grants FCC/1/1973-51-01, REI/1/4984-01, and BAS/1/ 1095-01-01 from King Abdullah University of Science and Technology (R.S.P.). Publisher Copyright: Copyright © 2023 Rosado et al.

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Exploring the Potential Molecular Mechanisms of Interactions between a Probiotic Consortium and Its Coral Host

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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