Exploring Nanocarriers as Treatment Modalities for Skin Cancer

Mohammad Adnan; Md Habban Akhter; Obaid Afzal; Abdulmalik S. A. Altamimi; Irfan Ahmad; Manal A. Alossaimi; Mariusz Jaremko; Abdul-Hamid M. Emwas; Tanweer Haider; Md. Faheem Haider

doi:10.3390/molecules28155905

Exploring Nanocarriers as Treatment Modalities for Skin Cancer

Mohammad Adnan, Md Habban Akhter, Obaid Afzal, Abdulmalik S. A. Altamimi, Irfan Ahmad, Manal A. Alossaimi, Mariusz Jaremko, Abdul-Hamid M. Emwas, Tanweer Haider, Md. Faheem Haider

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Cancer is a progressive disease of multi-factorial origin that has risen worldwide, probably due to changes in lifestyle, food intake, and environmental changes as some of the reasons. Skin cancer can be classified into melanomas from melanocytes and nonmelanoma skin cancer (NMSC) from the epidermally-derived cell. Together it constitutes about 95% of skin cancer. Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (CSCC) are creditworthy of 99% of NMSC due to the limited accessibility of conventional formulations in skin cancer cells of having multiple obstacles in treatment reply to this therapeutic regime. Despite this, it often encounters erratic bioavailability and absorption to the target. Nanoparticles developed through nanotechnology platforms could be the better topical skin cancer therapy option. To improve the topical delivery, the nano-sized delivery system is appropriate as it fuses with the cutaneous layer and fluidized membrane; thus, the deeper penetration of therapeutics could be possible to reach the target spot. This review briefly outlooks the various nanoparticle preparations, i.e., liposomes, niosomes, ethosomes, transferosomes, transethosomes, nanoemulsions, and nanoparticles technologies tested into skin cancer and impede their progress tend to concentrate in the skin layers. Nanocarriers have proved that they can considerably boost medication bioavailability, lowering the frequency of dosage and reducing the toxicity associated with high doses of the medication.

Original language	English (US)
Pages (from-to)	5905
Journal	Molecules
Volume	28
Issue number	15
DOIs	https://doi.org/10.3390/molecules28155905
State	Published - Aug 5 2023

Bibliographical note

KAUST Repository Item: Exported on 2023-08-08
Acknowledgements: This research was funded by Deanship of Scientific Research at King Khalid University grant number [RGP.02/260/44]. The authors express their gratitude to the Deanship of Scientific Research at King Khalid University for funding this work through a Large Research Group Project under grant number RGP.02/260/44. The authors are very thankful to the Research and Development department, Integral University Lucknow, for providing the necessary facilities required for completing this review work.

ASJC Scopus subject areas

Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/molecules28155905

https://repository.kaust.edu.sa/bitstream/10754/693505/1/molecules-28-05905.pdf

Cite this

@article{1556b85e855849d5beee8b7a82c4ffc7,

title = "Exploring Nanocarriers as Treatment Modalities for Skin Cancer",

abstract = "Cancer is a progressive disease of multi-factorial origin that has risen worldwide, probably due to changes in lifestyle, food intake, and environmental changes as some of the reasons. Skin cancer can be classified into melanomas from melanocytes and nonmelanoma skin cancer (NMSC) from the epidermally-derived cell. Together it constitutes about 95% of skin cancer. Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (CSCC) are creditworthy of 99% of NMSC due to the limited accessibility of conventional formulations in skin cancer cells of having multiple obstacles in treatment reply to this therapeutic regime. Despite this, it often encounters erratic bioavailability and absorption to the target. Nanoparticles developed through nanotechnology platforms could be the better topical skin cancer therapy option. To improve the topical delivery, the nano-sized delivery system is appropriate as it fuses with the cutaneous layer and fluidized membrane; thus, the deeper penetration of therapeutics could be possible to reach the target spot. This review briefly outlooks the various nanoparticle preparations, i.e., liposomes, niosomes, ethosomes, transferosomes, transethosomes, nanoemulsions, and nanoparticles technologies tested into skin cancer and impede their progress tend to concentrate in the skin layers. Nanocarriers have proved that they can considerably boost medication bioavailability, lowering the frequency of dosage and reducing the toxicity associated with high doses of the medication.",

author = "Mohammad Adnan and Akhter, {Md Habban} and Obaid Afzal and Altamimi, {Abdulmalik S. A.} and Irfan Ahmad and Alossaimi, {Manal A.} and Mariusz Jaremko and Emwas, {Abdul-Hamid M.} and Tanweer Haider and Haider, {Md. Faheem}",

note = "KAUST Repository Item: Exported on 2023-08-08 Acknowledgements: This research was funded by Deanship of Scientific Research at King Khalid University grant number [RGP.02/260/44]. The authors express their gratitude to the Deanship of Scientific Research at King Khalid University for funding this work through a Large Research Group Project under grant number RGP.02/260/44. The authors are very thankful to the Research and Development department, Integral University Lucknow, for providing the necessary facilities required for completing this review work.",

year = "2023",

month = aug,

day = "5",

doi = "10.3390/molecules28155905",

language = "English (US)",

volume = "28",

pages = "5905",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "15",

}

TY - JOUR

T1 - Exploring Nanocarriers as Treatment Modalities for Skin Cancer

AU - Adnan, Mohammad

AU - Akhter, Md Habban

AU - Afzal, Obaid

AU - Altamimi, Abdulmalik S. A.

AU - Ahmad, Irfan

AU - Alossaimi, Manal A.

AU - Jaremko, Mariusz

AU - Emwas, Abdul-Hamid M.

AU - Haider, Tanweer

AU - Haider, Md. Faheem

N1 - KAUST Repository Item: Exported on 2023-08-08 Acknowledgements: This research was funded by Deanship of Scientific Research at King Khalid University grant number [RGP.02/260/44]. The authors express their gratitude to the Deanship of Scientific Research at King Khalid University for funding this work through a Large Research Group Project under grant number RGP.02/260/44. The authors are very thankful to the Research and Development department, Integral University Lucknow, for providing the necessary facilities required for completing this review work.

PY - 2023/8/5

Y1 - 2023/8/5

N2 - Cancer is a progressive disease of multi-factorial origin that has risen worldwide, probably due to changes in lifestyle, food intake, and environmental changes as some of the reasons. Skin cancer can be classified into melanomas from melanocytes and nonmelanoma skin cancer (NMSC) from the epidermally-derived cell. Together it constitutes about 95% of skin cancer. Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (CSCC) are creditworthy of 99% of NMSC due to the limited accessibility of conventional formulations in skin cancer cells of having multiple obstacles in treatment reply to this therapeutic regime. Despite this, it often encounters erratic bioavailability and absorption to the target. Nanoparticles developed through nanotechnology platforms could be the better topical skin cancer therapy option. To improve the topical delivery, the nano-sized delivery system is appropriate as it fuses with the cutaneous layer and fluidized membrane; thus, the deeper penetration of therapeutics could be possible to reach the target spot. This review briefly outlooks the various nanoparticle preparations, i.e., liposomes, niosomes, ethosomes, transferosomes, transethosomes, nanoemulsions, and nanoparticles technologies tested into skin cancer and impede their progress tend to concentrate in the skin layers. Nanocarriers have proved that they can considerably boost medication bioavailability, lowering the frequency of dosage and reducing the toxicity associated with high doses of the medication.

AB - Cancer is a progressive disease of multi-factorial origin that has risen worldwide, probably due to changes in lifestyle, food intake, and environmental changes as some of the reasons. Skin cancer can be classified into melanomas from melanocytes and nonmelanoma skin cancer (NMSC) from the epidermally-derived cell. Together it constitutes about 95% of skin cancer. Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (CSCC) are creditworthy of 99% of NMSC due to the limited accessibility of conventional formulations in skin cancer cells of having multiple obstacles in treatment reply to this therapeutic regime. Despite this, it often encounters erratic bioavailability and absorption to the target. Nanoparticles developed through nanotechnology platforms could be the better topical skin cancer therapy option. To improve the topical delivery, the nano-sized delivery system is appropriate as it fuses with the cutaneous layer and fluidized membrane; thus, the deeper penetration of therapeutics could be possible to reach the target spot. This review briefly outlooks the various nanoparticle preparations, i.e., liposomes, niosomes, ethosomes, transferosomes, transethosomes, nanoemulsions, and nanoparticles technologies tested into skin cancer and impede their progress tend to concentrate in the skin layers. Nanocarriers have proved that they can considerably boost medication bioavailability, lowering the frequency of dosage and reducing the toxicity associated with high doses of the medication.

UR - http://hdl.handle.net/10754/693505

UR - https://www.mdpi.com/1420-3049/28/15/5905

U2 - 10.3390/molecules28155905

DO - 10.3390/molecules28155905

M3 - Article

C2 - 37570875

SN - 1420-3049

VL - 28

SP - 5905

JO - Molecules

JF - Molecules

IS - 15

ER -

Exploring Nanocarriers as Treatment Modalities for Skin Cancer

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this