Expedient Syntheses of Neutral and Cationic Au(I)–NHC Complexes

Richard M. P. Veenboer; Danila Gasperini; Fady Nahra; David B. Cordes; Alexandra M. Z. Slawin; Catherine S. J. Cazin; Steven P. Nolan

doi:10.1021/acs.organomet.7b00622

Expedient Syntheses of Neutral and Cationic Au(I)–NHC Complexes

Richard M. P. Veenboer, Danila Gasperini, Fady Nahra, David B. Cordes, Alexandra M. Z. Slawin, Catherine S. J. Cazin, Steven P. Nolan

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21 Scopus citations

Abstract

The synthesis and isolation of gold(I) precatalysts often requires the generation of several isolable intermediates as well as numerous purification steps. New protocols for the expedient synthesis of neutral [Au(OH)(NHC)] and [Au(CH2COCH3)(NHC)] species from [AuCl(NHC)] or [AuCl(DMS)] precursors bearing a variety of N-heterocyclic carbene (NHC) ligands are presented. These methods can be employed in a telescoping manner for the synthesis of catalytically relevant [Au(NTf2)(NHC)] and [Au(NHC)(NCCH3)][BF4] complexes. These attractive methods are straightforward and practical leading to various complexes in high isolated yields and purity.

Original language	English (US)
Pages (from-to)	3645-3653
Number of pages	9
Journal	Organometallics
Volume	36
Issue number	18
DOIs	https://doi.org/10.1021/acs.organomet.7b00622
State	Published - Sep 8 2017
Externally published	Yes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The European Research Council (ERC) and the Engineering and Physical Sciences Research Council (EPSRC), UK are gratefully acknowledged for their support. Umicore AG is thanked for generous donations of auric acid. The EPSRC National Mass Spectrometry Service Centre (NMSSC) is gratefully acknowledged for HRMS analyses. S.P.N. thanks the King Abdullah University of Science and Technology (KAUST) for support. Dr Alberto Gómez Herrera is thanked for synthetic contributions.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

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10.1021/acs.organomet.7b00622

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title = "Expedient Syntheses of Neutral and Cationic Au(I)–NHC Complexes",

abstract = "The synthesis and isolation of gold(I) precatalysts often requires the generation of several isolable intermediates as well as numerous purification steps. New protocols for the expedient synthesis of neutral [Au(OH)(NHC)] and [Au(CH2COCH3)(NHC)] species from [AuCl(NHC)] or [AuCl(DMS)] precursors bearing a variety of N-heterocyclic carbene (NHC) ligands are presented. These methods can be employed in a telescoping manner for the synthesis of catalytically relevant [Au(NTf2)(NHC)] and [Au(NHC)(NCCH3)][BF4] complexes. These attractive methods are straightforward and practical leading to various complexes in high isolated yields and purity.",

author = "Veenboer, {Richard M. P.} and Danila Gasperini and Fady Nahra and Cordes, {David B.} and Slawin, {Alexandra M. Z.} and Cazin, {Catherine S. J.} and Nolan, {Steven P.}",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The European Research Council (ERC) and the Engineering and Physical Sciences Research Council (EPSRC), UK are gratefully acknowledged for their support. Umicore AG is thanked for generous donations of auric acid. The EPSRC National Mass Spectrometry Service Centre (NMSSC) is gratefully acknowledged for HRMS analyses. S.P.N. thanks the King Abdullah University of Science and Technology (KAUST) for support. Dr Alberto G{\'o}mez Herrera is thanked for synthetic contributions. This publication acknowledges KAUST support, but has no KAUST affiliated authors.",

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doi = "10.1021/acs.organomet.7b00622",

language = "English (US)",

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AU - Veenboer, Richard M. P.

AU - Gasperini, Danila

AU - Nahra, Fady

AU - Cordes, David B.

AU - Slawin, Alexandra M. Z.

AU - Cazin, Catherine S. J.

AU - Nolan, Steven P.

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The European Research Council (ERC) and the Engineering and Physical Sciences Research Council (EPSRC), UK are gratefully acknowledged for their support. Umicore AG is thanked for generous donations of auric acid. The EPSRC National Mass Spectrometry Service Centre (NMSSC) is gratefully acknowledged for HRMS analyses. S.P.N. thanks the King Abdullah University of Science and Technology (KAUST) for support. Dr Alberto Gómez Herrera is thanked for synthetic contributions. This publication acknowledges KAUST support, but has no KAUST affiliated authors.

PY - 2017/9/8

Y1 - 2017/9/8

N2 - The synthesis and isolation of gold(I) precatalysts often requires the generation of several isolable intermediates as well as numerous purification steps. New protocols for the expedient synthesis of neutral [Au(OH)(NHC)] and [Au(CH2COCH3)(NHC)] species from [AuCl(NHC)] or [AuCl(DMS)] precursors bearing a variety of N-heterocyclic carbene (NHC) ligands are presented. These methods can be employed in a telescoping manner for the synthesis of catalytically relevant [Au(NTf2)(NHC)] and [Au(NHC)(NCCH3)][BF4] complexes. These attractive methods are straightforward and practical leading to various complexes in high isolated yields and purity.

AB - The synthesis and isolation of gold(I) precatalysts often requires the generation of several isolable intermediates as well as numerous purification steps. New protocols for the expedient synthesis of neutral [Au(OH)(NHC)] and [Au(CH2COCH3)(NHC)] species from [AuCl(NHC)] or [AuCl(DMS)] precursors bearing a variety of N-heterocyclic carbene (NHC) ligands are presented. These methods can be employed in a telescoping manner for the synthesis of catalytically relevant [Au(NTf2)(NHC)] and [Au(NHC)(NCCH3)][BF4] complexes. These attractive methods are straightforward and practical leading to various complexes in high isolated yields and purity.

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DO - 10.1021/acs.organomet.7b00622

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JO - Organometallics

JF - Organometallics

IS - 18

ER -

Expedient Syntheses of Neutral and Cationic Au(I)–NHC Complexes

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