Exercise Enhances SIRT1 Expression and Improves Alzheimer’s Disease 运动提高沉默信息调节因子 2 相关酶 1 改善阿尔兹海默症

Ke Chen, Xiang Liang Zhang, Li Tao Du

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Alzheimer’s disease (AD) is a neurodegenerative disease, β-amyloid (Aβ) deposition and Tau protein hyperphosphorylation are the main pathological features. Silent mating-type information regulation 2 homolog 1 (SIRT1) can deacetylate various types of histones and non-histones, and play an important role in the pathogenesis of AD. Recent studies found that exercise can activate SIRT1 to delay the progression of AD. The mechanisms may be as follows: inhibit the activity of β-secretase and increase the activity of α-secretase to reduce the production of Aβ; reduce the accumulation of hyperphosphorylated Tau protein; interact with PGC-1α to promote mitochondrial biogenesis; up-regulate PINK1/ Parkin signaling pathway to improve mitochondrial autophagy; and deacetylate NF-κB to inhibit neuroinflammation. In addition, the protein levels of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in hippocampus are increased, and ApoE4 gene is inhibited to enhance synaptic plasticity. This article summarizes the role and mechanisms of exercise in improving AD by regulating SIRT1, and provides new ideas for the prevention and treatment of AD.
Original languageEnglish (US)
Pages (from-to)563-569
Number of pages7
JournalChinese Journal of Biochemistry and Molecular Biology
Issue number5
StatePublished - May 20 2022
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-09-20


Dive into the research topics of 'Exercise Enhances SIRT1 Expression and Improves Alzheimer’s Disease 运动提高沉默信息调节因子 2 相关酶 1 改善阿尔兹海默症'. Together they form a unique fingerprint.

Cite this