Examining histone modification crosstalk using immobilized libraries established from ligation-ready nucleosomes

Diego Aparicio Pelaz, Zhadyra Yerkesh, Sören Kirchgäßner, Henriette Mahler, Vladlena Kharchenko, Dulat Azhibek, Mariusz Jaremko, Henning D. Mootz, Lukasz Jaremko, Dirk Schwarzer, Wolfgang Fischle

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

280 different patterns of histone modifications were installed in preassembled nucleosomes using PTS and SML enabling screening of readout crosstalk.
Original languageEnglish (US)
JournalChemical Science
DOIs
StatePublished - Aug 20 2020

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by the priority program SPP 1623 of the Deutsche Forschungsgemeinscha (DFG FI1513/3-1 to W. F. and SCHW1163/4-1 to D. S.) the Max Planck Society (W. F.), and intramural funds of King Abdullah University of Science and Technology (M. J., L. J. and W. F.). We thank members of the HDM group for help with establishing protein trans-splicing assays.

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