Evolutionarily conserved transcription factor Apontic controls the G1/S progression by inducing cyclin e during eye development

Qingxin Liu; Xianfeng Wang; Kazuho Ikeo; Susumu Hirose; Walter Jakob Gehring; Takashi Gojobori

doi:10.1073/pnas.1407145111

Evolutionarily conserved transcription factor Apontic controls the G1/S progression by inducing cyclin e during eye development

Qingxin Liu, Xianfeng Wang, Kazuho Ikeo, Susumu Hirose, Walter Jakob Gehring, Takashi Gojobori

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Abstract

During Drosophila eye development, differentiation initiates in the posterior region of the eye disk and progresses anteriorly as a wave marked by the morphogenetic furrow (MF), which demarcates the boundary between anterior undifferentiated cells and posterior differentiated photoreceptors. However, the mechanism underlying the regulation of gene expression immediately before the onset of differentiation remains unclear. Here, we show that Apontic (Apt), which is an evolutionarily conserved transcription factor, is expressed in the differentiating cells posterior to the MF. Moreover, it directly induces the expression of cyclin E and is also required for the G1-to-S phase transition, which is known to be essential for the initiation of cell differentiation at the MF. These observations identify a pathway crucial for eye development, governed by a mechanism in which Cyclin E promotes the G1-to-S phase transition when regulated by Apt.

Original language	English (US)
Pages (from-to)	9497-9502
Number of pages	6
Journal	Proceedings of the National Academy of Sciences
Volume	111
Issue number	26
DOIs	https://doi.org/10.1073/pnas.1407145111
State	Published - Jun 16 2014

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We thank Helena Richardson for Cyclin E antibody and Yash Hiromi for valuable suggestions. This work was supported by National Basic Research Program of China Grant 2012CB114600 (to Q.-X. L. and X.-F.W.), a Grant in Aid for Scientific Research (to S. H.), and a Research Grant for the Cell Innovation Project from the Ministry of Education, Culture, Sports, Science and Technology of Japan (to K.I. and T.G.).

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title = "Evolutionarily conserved transcription factor Apontic controls the G1/S progression by inducing cyclin e during eye development",

abstract = "During Drosophila eye development, differentiation initiates in the posterior region of the eye disk and progresses anteriorly as a wave marked by the morphogenetic furrow (MF), which demarcates the boundary between anterior undifferentiated cells and posterior differentiated photoreceptors. However, the mechanism underlying the regulation of gene expression immediately before the onset of differentiation remains unclear. Here, we show that Apontic (Apt), which is an evolutionarily conserved transcription factor, is expressed in the differentiating cells posterior to the MF. Moreover, it directly induces the expression of cyclin E and is also required for the G1-to-S phase transition, which is known to be essential for the initiation of cell differentiation at the MF. These observations identify a pathway crucial for eye development, governed by a mechanism in which Cyclin E promotes the G1-to-S phase transition when regulated by Apt.",

author = "Qingxin Liu and Xianfeng Wang and Kazuho Ikeo and Susumu Hirose and Gehring, {Walter Jakob} and Takashi Gojobori",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: We thank Helena Richardson for Cyclin E antibody and Yash Hiromi for valuable suggestions. This work was supported by National Basic Research Program of China Grant 2012CB114600 (to Q.-X. L. and X.-F.W.), a Grant in Aid for Scientific Research (to S. H.), and a Research Grant for the Cell Innovation Project from the Ministry of Education, Culture, Sports, Science and Technology of Japan (to K.I. and T.G.).",

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doi = "10.1073/pnas.1407145111",

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AU - Liu, Qingxin

AU - Wang, Xianfeng

AU - Ikeo, Kazuho

AU - Hirose, Susumu

AU - Gehring, Walter Jakob

AU - Gojobori, Takashi

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: We thank Helena Richardson for Cyclin E antibody and Yash Hiromi for valuable suggestions. This work was supported by National Basic Research Program of China Grant 2012CB114600 (to Q.-X. L. and X.-F.W.), a Grant in Aid for Scientific Research (to S. H.), and a Research Grant for the Cell Innovation Project from the Ministry of Education, Culture, Sports, Science and Technology of Japan (to K.I. and T.G.).

PY - 2014/6/16

Y1 - 2014/6/16

N2 - During Drosophila eye development, differentiation initiates in the posterior region of the eye disk and progresses anteriorly as a wave marked by the morphogenetic furrow (MF), which demarcates the boundary between anterior undifferentiated cells and posterior differentiated photoreceptors. However, the mechanism underlying the regulation of gene expression immediately before the onset of differentiation remains unclear. Here, we show that Apontic (Apt), which is an evolutionarily conserved transcription factor, is expressed in the differentiating cells posterior to the MF. Moreover, it directly induces the expression of cyclin E and is also required for the G1-to-S phase transition, which is known to be essential for the initiation of cell differentiation at the MF. These observations identify a pathway crucial for eye development, governed by a mechanism in which Cyclin E promotes the G1-to-S phase transition when regulated by Apt.

AB - During Drosophila eye development, differentiation initiates in the posterior region of the eye disk and progresses anteriorly as a wave marked by the morphogenetic furrow (MF), which demarcates the boundary between anterior undifferentiated cells and posterior differentiated photoreceptors. However, the mechanism underlying the regulation of gene expression immediately before the onset of differentiation remains unclear. Here, we show that Apontic (Apt), which is an evolutionarily conserved transcription factor, is expressed in the differentiating cells posterior to the MF. Moreover, it directly induces the expression of cyclin E and is also required for the G1-to-S phase transition, which is known to be essential for the initiation of cell differentiation at the MF. These observations identify a pathway crucial for eye development, governed by a mechanism in which Cyclin E promotes the G1-to-S phase transition when regulated by Apt.

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Evolutionarily conserved transcription factor Apontic controls the G1/S progression by inducing cyclin e during eye development

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