Evolutionarily conserved transcription factor Apontic controls the G1/S progression by inducing cyclin e during eye development

Qingxin Liu, Xianfeng Wang, Kazuho Ikeo, Susumu Hirose, Walter Jakob Gehring, Takashi Gojobori

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


During Drosophila eye development, differentiation initiates in the posterior region of the eye disk and progresses anteriorly as a wave marked by the morphogenetic furrow (MF), which demarcates the boundary between anterior undifferentiated cells and posterior differentiated photoreceptors. However, the mechanism underlying the regulation of gene expression immediately before the onset of differentiation remains unclear. Here, we show that Apontic (Apt), which is an evolutionarily conserved transcription factor, is expressed in the differentiating cells posterior to the MF. Moreover, it directly induces the expression of cyclin E and is also required for the G1-to-S phase transition, which is known to be essential for the initiation of cell differentiation at the MF. These observations identify a pathway crucial for eye development, governed by a mechanism in which Cyclin E promotes the G1-to-S phase transition when regulated by Apt.
Original languageEnglish (US)
Pages (from-to)9497-9502
Number of pages6
JournalProceedings of the National Academy of Sciences
Issue number26
StatePublished - Jun 16 2014

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We thank Helena Richardson for Cyclin E antibody and Yash Hiromi for valuable suggestions. This work was supported by National Basic Research Program of China Grant 2012CB114600 (to Q.-X. L. and X.-F.W.), a Grant in Aid for Scientific Research (to S. H.), and a Research Grant for the Cell Innovation Project from the Ministry of Education, Culture, Sports, Science and Technology of Japan (to K.I. and T.G.).

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Evolutionarily conserved transcription factor Apontic controls the G1/S progression by inducing cyclin e during eye development'. Together they form a unique fingerprint.

Cite this