Evidence for a susceptibility gene for anorexia nervosa on chromosome 1

D. E. Grice, K. A. Halmi, M. M. Fichter, M. Strober, D. B. Woodside, J. T. Treasure, A. S. Kaplan, P. J. Magistretti, D. Goldman, C. M. Bulik, W. H. Kaye, W. H. Berrettini

Research output: Contribution to journalArticlepeer-review

199 Scopus citations

Abstract

Eating disorders, such as anorexia nervosa (AN), have a significant genetic component. In the current study, a genomewide linkage analysis of 192 families with at least one affected relative pair with AN and related eating disorders, including bulimia nervosa, was performed, resulting in only modest evidence for linkage, with the highest nonparametric linkage (NPL) score, 1.80, at marker D4S2367 on chromosome 4. Since the reduction of sample heterogeneity would increase power to detect linkage, we performed linkage analysis in a subset (n = 37) of families in which at least two affected relatives had diagnoses of restricting AN, a clinically defined subtype of AN characterized by severe limitation of food intake without the presence of binge-eating or purging behavior. When we limited the linkage analysis to this clinically more homogeneous subgroup, the highest multipoint NPL score observed was 3.03, at marker D1S3721 on chromosome 1p. The genotyping of additional markers in this region led to a peak multipoint NPL score of 3.45, thereby providing suggestive evidence for the presence of an AN-susceptibility locus on chromosome 1p.

Original languageEnglish (US)
Pages (from-to)787-792
Number of pages6
JournalAmerican Journal of Human Genetics
Volume70
Issue number3
DOIs
StatePublished - Mar 2002
Externally publishedYes

Bibliographical note

Funding Information:
The authors wish to thank the Price Foundation for the support of the clinical collection of subjects, genotyping, and data analysis. Genotypic markers, allele frequencies, and genetic maps were generated at the Center for Medical Genetics, Marshfield Medical Research Foundation, with support from the National Heart, Lung and Blood Institute. The authors are indebted to the participating families for their contributions of time and effort in support of this study.

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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