Abstract
The present work describes the formulation and evaluation of the gastroretentive system of Itopride hydrochloride. In this research, we have formulated floating hydrogel-based microspheres employing calcium carbonate (CaCO3) as a gas forming agent dispersed in alginate matrix. In vitro characterizations such as drug content, particle size, and drug release were carried out. GI motility was determined by administration of charcoal meal to rats. Results demonstrated that prepared microspheres were spherical in shape with smooth surface, good loading efficiency, and excellent buoyancy. The gastro retentive dosage form of itiopride demonstrated significant antacid, anti-ulcer, and anti-GERD activity after 12 hours in comparison with the conventional dosage form. © 2010 Informa UK Ltd.
Original language | English (US) |
---|---|
Pages (from-to) | 200-207 |
Number of pages | 8 |
Journal | Artificial Cells, Blood Substitutes, and Biotechnology |
Volume | 38 |
Issue number | 4 |
DOIs | |
State | Published - Aug 1 2010 |
Externally published | Yes |
Bibliographical note
Generated from Scopus record by KAUST IRTS on 2023-10-12ASJC Scopus subject areas
- Biomedical Engineering
- Biotechnology