Evaluation of anti-GERD activity of gastro retentive drug delivery system of itopride hydrochloride

Trilochan Satapathy, Prasana K. Panda, Amit K. Goyal, Goutam Rath

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The present work describes the formulation and evaluation of the gastroretentive system of Itopride hydrochloride. In this research, we have formulated floating hydrogel-based microspheres employing calcium carbonate (CaCO3) as a gas forming agent dispersed in alginate matrix. In vitro characterizations such as drug content, particle size, and drug release were carried out. GI motility was determined by administration of charcoal meal to rats. Results demonstrated that prepared microspheres were spherical in shape with smooth surface, good loading efficiency, and excellent buoyancy. The gastro retentive dosage form of itiopride demonstrated significant antacid, anti-ulcer, and anti-GERD activity after 12 hours in comparison with the conventional dosage form. © 2010 Informa UK Ltd.
Original languageEnglish (US)
Pages (from-to)200-207
Number of pages8
JournalArtificial Cells, Blood Substitutes, and Biotechnology
Issue number4
StatePublished - Aug 1 2010
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-10-12

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biotechnology


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