Epigenome programming by Polycomb and Trithorax proteins

Filippo M. Cernilogar, Valerio Orlando*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Polycomb group (PcG) and Trithorax group (TrxG) proteins work, respectively, to maintain repressed or active transcription states of developmentally regulated genes through cell division. Data accumulated in the recent years have increased our understanding of the mechanisms by which PcG and TrxG proteins regulate gene expression. The discovery that histone methylation can serve as a specific mark for PcG and TrxG complexes has provided new insight into the mechanistic function of this cell-memory system.

Original languageEnglish (US)
Pages (from-to)322-331
Number of pages10
JournalBiochemistry and Cell Biology
Issue number3
StatePublished - Jun 2005
Externally publishedYes


  • Cell memory
  • Epigenome
  • Noncoding RNA
  • Polycomb
  • RNAi
  • Trithorax

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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