Enhancement of neurite outgrowth in neuronal-like cells following boron nitride nanotube-mediated stimulation

Gianni Ciofani; Serena Danti; Delfo D'Alessandro; Leonardo Ricotti; Stefania Moscato; Giovanni Bertoni; Andrea Falqui; Stefano Berrettini; Mario Petrini; Virgilio Mattoli; Arianna Menciassi

doi:10.1021/nn101985a

Enhancement of neurite outgrowth in neuronal-like cells following boron nitride nanotube-mediated stimulation

Gianni Ciofani^*, Serena Danti, Delfo D'Alessandro, Leonardo Ricotti, Stefania Moscato, Giovanni Bertoni, Andrea Falqui, Stefano Berrettini, Mario Petrini, Virgilio Mattoli, Arianna Menciassi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

213 Scopus citations

Abstract

In this paper, we propose an absolutely innovative technique for the electrical stimulation of cells, based on piezoelectric nanoparticles. Ultrasounds are used to impart mechanical stress to boron nitride nanotubes incubated with neuronal-like PC12 cells. By virtue of their piezoelectric properties, these nanotubes can polarize and convey electrical stimuli to the cells. PC12 stimulated with the present method exhibit neurite sprout 30% greater than the control cultures after 9 days of treatment.

Original language	English (US)
Pages (from-to)	6267-6277
Number of pages	11
Journal	ACS Nano
Volume	4
Issue number	10
DOIs	https://doi.org/10.1021/nn101985a
State	Published - Oct 26 2010
Externally published	Yes

Keywords

PC12 cells
boron nitride nanotubes
neuronal regeneration
piezoelectric stimulation

ASJC Scopus subject areas

General Materials Science
General Engineering
General Physics and Astronomy

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10.1021/nn101985a

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title = "Enhancement of neurite outgrowth in neuronal-like cells following boron nitride nanotube-mediated stimulation",

abstract = "In this paper, we propose an absolutely innovative technique for the electrical stimulation of cells, based on piezoelectric nanoparticles. Ultrasounds are used to impart mechanical stress to boron nitride nanotubes incubated with neuronal-like PC12 cells. By virtue of their piezoelectric properties, these nanotubes can polarize and convey electrical stimuli to the cells. PC12 stimulated with the present method exhibit neurite sprout 30% greater than the control cultures after 9 days of treatment.",

keywords = "PC12 cells, boron nitride nanotubes, neuronal regeneration, piezoelectric stimulation",

author = "Gianni Ciofani and Serena Danti and Delfo D'Alessandro and Leonardo Ricotti and Stefania Moscato and Giovanni Bertoni and Andrea Falqui and Stefano Berrettini and Mario Petrini and Virgilio Mattoli and Arianna Menciassi",

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T1 - Enhancement of neurite outgrowth in neuronal-like cells following boron nitride nanotube-mediated stimulation

AU - Ciofani, Gianni

AU - Danti, Serena

AU - D'Alessandro, Delfo

AU - Ricotti, Leonardo

AU - Moscato, Stefania

AU - Bertoni, Giovanni

AU - Falqui, Andrea

AU - Berrettini, Stefano

AU - Petrini, Mario

AU - Mattoli, Virgilio

AU - Menciassi, Arianna

PY - 2010/10/26

Y1 - 2010/10/26

N2 - In this paper, we propose an absolutely innovative technique for the electrical stimulation of cells, based on piezoelectric nanoparticles. Ultrasounds are used to impart mechanical stress to boron nitride nanotubes incubated with neuronal-like PC12 cells. By virtue of their piezoelectric properties, these nanotubes can polarize and convey electrical stimuli to the cells. PC12 stimulated with the present method exhibit neurite sprout 30% greater than the control cultures after 9 days of treatment.

AB - In this paper, we propose an absolutely innovative technique for the electrical stimulation of cells, based on piezoelectric nanoparticles. Ultrasounds are used to impart mechanical stress to boron nitride nanotubes incubated with neuronal-like PC12 cells. By virtue of their piezoelectric properties, these nanotubes can polarize and convey electrical stimuli to the cells. PC12 stimulated with the present method exhibit neurite sprout 30% greater than the control cultures after 9 days of treatment.

KW - PC12 cells

KW - boron nitride nanotubes

KW - neuronal regeneration

KW - piezoelectric stimulation

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JO - ACS Nano

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ER -

Enhancement of neurite outgrowth in neuronal-like cells following boron nitride nanotube-mediated stimulation

Abstract

Keywords

ASJC Scopus subject areas

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