Engineering crops of the future: CRISPR approaches to develop climate-resilient and disease-resistant plants

Syed Shan-e-Ali Zaidi; Ahmed Mahas; Hervé Vanderschuren; Magdy M. Mahfouz

doi:10.1186/s13059-020-02204-y

Engineering crops of the future: CRISPR approaches to develop climate-resilient and disease-resistant plants

Syed Shan-e-Ali Zaidi, Ahmed Mahas, Hervé Vanderschuren, Magdy M. Mahfouz

Research output: Contribution to journal › Article › peer-review

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Abstract

AbstractTo meet increasing global food demand, breeders and scientists aim to improve the yield and quality of major food crops. Plant diseases threaten food security and are expected to increase because of climate change. CRISPR genome-editing technology opens new opportunities to engineer disease resistance traits. With precise genome engineering and transgene-free applications, CRISPR is expected to resolve the major challenges to crop improvement. Here, we discuss the latest developments in CRISPR technologies for engineering resistance to viruses, bacteria, fungi, and pests. We conclude by highlighting current concerns and gaps in technology, as well as outstanding questions for future research.

Original language	English (US)
Journal	Genome biology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s13059-020-02204-y
State	Published - Nov 30 2020

Bibliographical note

KAUST Repository Item: Exported on 2020-12-02
Acknowledged KAUST grant number(s): OSR-2015-CRG4-2647
Acknowledgements: We wish to thank members of the Laboratory for Genome Engineering and Synthetic Biology at King Abdullah University of Science and Technology for helpful discussions and comments on the manuscript.

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10.1186/s13059-020-02204-y

https://repository.kaust.edu.sa/bitstream/10754/666173/1/Articlefile1.pdf

Cite this

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title = "Engineering crops of the future: CRISPR approaches to develop climate-resilient and disease-resistant plants",

abstract = "AbstractTo meet increasing global food demand, breeders and scientists aim to improve the yield and quality of major food crops. Plant diseases threaten food security and are expected to increase because of climate change. CRISPR genome-editing technology opens new opportunities to engineer disease resistance traits. With precise genome engineering and transgene-free applications, CRISPR is expected to resolve the major challenges to crop improvement. Here, we discuss the latest developments in CRISPR technologies for engineering resistance to viruses, bacteria, fungi, and pests. We conclude by highlighting current concerns and gaps in technology, as well as outstanding questions for future research.",

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AU - Mahfouz, Magdy M.

N1 - KAUST Repository Item: Exported on 2020-12-02 Acknowledged KAUST grant number(s): OSR-2015-CRG4-2647 Acknowledgements: We wish to thank members of the Laboratory for Genome Engineering and Synthetic Biology at King Abdullah University of Science and Technology for helpful discussions and comments on the manuscript.

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N2 - AbstractTo meet increasing global food demand, breeders and scientists aim to improve the yield and quality of major food crops. Plant diseases threaten food security and are expected to increase because of climate change. CRISPR genome-editing technology opens new opportunities to engineer disease resistance traits. With precise genome engineering and transgene-free applications, CRISPR is expected to resolve the major challenges to crop improvement. Here, we discuss the latest developments in CRISPR technologies for engineering resistance to viruses, bacteria, fungi, and pests. We conclude by highlighting current concerns and gaps in technology, as well as outstanding questions for future research.

AB - AbstractTo meet increasing global food demand, breeders and scientists aim to improve the yield and quality of major food crops. Plant diseases threaten food security and are expected to increase because of climate change. CRISPR genome-editing technology opens new opportunities to engineer disease resistance traits. With precise genome engineering and transgene-free applications, CRISPR is expected to resolve the major challenges to crop improvement. Here, we discuss the latest developments in CRISPR technologies for engineering resistance to viruses, bacteria, fungi, and pests. We conclude by highlighting current concerns and gaps in technology, as well as outstanding questions for future research.

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Engineering crops of the future: CRISPR approaches to develop climate-resilient and disease-resistant plants

Abstract

Bibliographical note

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