Elucidation of the alternating copolymerization mechanism of epoxides or aziridines with cyclic anhydrides in the presence of halide salts

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10 Scopus citations

Abstract

Organic halide salts in combination with metal or Lewis acids are the most common and essential catalysts in ring-opening copolymerizations (ROCOP). However, the role of organic halide salts was neglected. Here, we have uncovered the complex behavior of organic halide in ROCOP of epoxides or aziridines with cyclic anhydrides. Coordination of the chain-end cations, electron-withdrawing effect, leaving ability of halide atoms, chain-end basicity/nucleophilicity, and terminal steric hindrance cause three types of side reactions: single-site transesterification, substitution, and elimination. Understanding the complex functions of organic halide salts in ROCOP led us to develop highly active and selective aminocyclopropenium chlorides as catalysts/initiators. Adjustable H-bonding interactions of aminocyclopropenium with propagating anions and epoxides create chain-end coordination processes that generate highly reactive carboxylate and highly selective alkoxide chain ends.
Original languageEnglish (US)
JournalAngewandte Chemie
DOIs
StatePublished - Feb 3 2023

Bibliographical note

KAUST Repository Item: Exported on 2023-05-28
Acknowledgements: The research work was supported by King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. For computer time, this research used the resources of the Supercomputing Laboratory at KAUST.

ASJC Scopus subject areas

  • General Medicine

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