Electrostatic assembly/disassembly of nanoscaled colloidosomes for light-triggered cargo release

Song Li; Basem Moosa; Jonas G. Croissant; Niveen M. Khashab

doi:10.1002/anie.201501615

Electrostatic assembly/disassembly of nanoscaled colloidosomes for light-triggered cargo release

Song Li, Basem Moosa, Jonas G. Croissant, Niveen M. Khashab

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Colloidosome capsules possess the potential for the encapsulation and release of molecular and macromolecular cargos. However, the stabilization of the colloidosome shell usually requires an additional covalent crosslinking which irreversibly seals the capsules, and greatly limits their applications in large-cargos release. Herein we report nanoscaled colloidosomes designed by the electrostatic assembly of organosilica nanoparticles (NPs) with oppositely charged surfaces (rather than covalent bonds), arising from different contents of a bridged nitrophenylene-alkoxysilane [NB; 3-nitro-N-(3-(triethoxysilyl)propyl)-4-(((3-(triethoxysilyl)propyl)-amino)methyl)benzamid] derivative in the silica. The surface charge of the positively charged NPs was reversed by light irradiation because of a photoreaction in the NB moieties, which impacted the electrostatic interactions between NPs and disassembled the colloidosome nanosystems. This design was successfully applied for the encapsulation and light-triggered release of cargos. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Original language	English (US)
Pages (from-to)	6804-6808
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	54
Issue number	23
DOIs	https://doi.org/10.1002/anie.201501615 https://doi.org/10.1002/ange.201501615 https://doi.org/10.1002/anie.201504211 https://doi.org/10.1002/ange.201504211
State	Published - Apr 27 2015

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We gratefully acknowledge support from King Abdullah University of Science and Technology (KAUST).

ASJC Scopus subject areas

General Chemistry
Catalysis

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Li, S., Moosa, B., Croissant, J. G., & Khashab, N. M. (2015). Electrostatic assembly/disassembly of nanoscaled colloidosomes for light-triggered cargo release. Angewandte Chemie - International Edition, 54(23), 6804-6808. https://doi.org/10.1002/anie.201501615, https://doi.org/10.1002/ange.201501615, https://doi.org/10.1002/anie.201504211, https://doi.org/10.1002/ange.201504211

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title = "Electrostatic assembly/disassembly of nanoscaled colloidosomes for light-triggered cargo release",

abstract = "Colloidosome capsules possess the potential for the encapsulation and release of molecular and macromolecular cargos. However, the stabilization of the colloidosome shell usually requires an additional covalent crosslinking which irreversibly seals the capsules, and greatly limits their applications in large-cargos release. Herein we report nanoscaled colloidosomes designed by the electrostatic assembly of organosilica nanoparticles (NPs) with oppositely charged surfaces (rather than covalent bonds), arising from different contents of a bridged nitrophenylene-alkoxysilane [NB; 3-nitro-N-(3-(triethoxysilyl)propyl)-4-(((3-(triethoxysilyl)propyl)-amino)methyl)benzamid] derivative in the silica. The surface charge of the positively charged NPs was reversed by light irradiation because of a photoreaction in the NB moieties, which impacted the electrostatic interactions between NPs and disassembled the colloidosome nanosystems. This design was successfully applied for the encapsulation and light-triggered release of cargos. {\textcopyright} 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

author = "Song Li and Basem Moosa and Croissant, {Jonas G.} and Khashab, {Niveen M.}",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: We gratefully acknowledge support from King Abdullah University of Science and Technology (KAUST).",

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Li, S, Moosa, B, Croissant, JG & Khashab, NM 2015, 'Electrostatic assembly/disassembly of nanoscaled colloidosomes for light-triggered cargo release', Angewandte Chemie - International Edition, vol. 54, no. 23, pp. 6804-6808. https://doi.org/10.1002/anie.201501615, https://doi.org/10.1002/ange.201501615, https://doi.org/10.1002/anie.201504211, https://doi.org/10.1002/ange.201504211

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N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: We gratefully acknowledge support from King Abdullah University of Science and Technology (KAUST).

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N2 - Colloidosome capsules possess the potential for the encapsulation and release of molecular and macromolecular cargos. However, the stabilization of the colloidosome shell usually requires an additional covalent crosslinking which irreversibly seals the capsules, and greatly limits their applications in large-cargos release. Herein we report nanoscaled colloidosomes designed by the electrostatic assembly of organosilica nanoparticles (NPs) with oppositely charged surfaces (rather than covalent bonds), arising from different contents of a bridged nitrophenylene-alkoxysilane [NB; 3-nitro-N-(3-(triethoxysilyl)propyl)-4-(((3-(triethoxysilyl)propyl)-amino)methyl)benzamid] derivative in the silica. The surface charge of the positively charged NPs was reversed by light irradiation because of a photoreaction in the NB moieties, which impacted the electrostatic interactions between NPs and disassembled the colloidosome nanosystems. This design was successfully applied for the encapsulation and light-triggered release of cargos. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

AB - Colloidosome capsules possess the potential for the encapsulation and release of molecular and macromolecular cargos. However, the stabilization of the colloidosome shell usually requires an additional covalent crosslinking which irreversibly seals the capsules, and greatly limits their applications in large-cargos release. Herein we report nanoscaled colloidosomes designed by the electrostatic assembly of organosilica nanoparticles (NPs) with oppositely charged surfaces (rather than covalent bonds), arising from different contents of a bridged nitrophenylene-alkoxysilane [NB; 3-nitro-N-(3-(triethoxysilyl)propyl)-4-(((3-(triethoxysilyl)propyl)-amino)methyl)benzamid] derivative in the silica. The surface charge of the positively charged NPs was reversed by light irradiation because of a photoreaction in the NB moieties, which impacted the electrostatic interactions between NPs and disassembled the colloidosome nanosystems. This design was successfully applied for the encapsulation and light-triggered release of cargos. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Electrostatic assembly/disassembly of nanoscaled colloidosomes for light-triggered cargo release

Abstract

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