Electrophilic N-Trifluoromethylthiophthalimide as a Fluorinated Reagent in the Synthesis of Acyl Fluorides

Chen Zhu, Serik Zhumagazy, Huifeng Yue, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Herein we report the deoxygenated fluorination of readily available carboxylic acids. A series of acyl fluorides have been synthesized using shelf-stable N-trifluoromethylthiophthalimide as a fluorinated reagent for the first time. Scale-up reactions and sequential cross-couplings were performed successfully to demonstrate the practicability of this fluorination protocol.
Original languageEnglish (US)
JournalOrganic Chemistry Frontiers
DOIs
StatePublished - 2021

Bibliographical note

KAUST Repository Item: Exported on 2022-01-27

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Electrophilic N-Trifluoromethylthiophthalimide as a Fluorinated Reagent in the Synthesis of Acyl Fluorides'. Together they form a unique fingerprint.

Cite this