Electrochemical synthesis of diverse allenes through controllable transformations of 1,3-enynes

Chen Zhu; Magnus Rueping

doi:10.1038/s44160-023-00350-2

Electrochemical synthesis of diverse allenes through controllable transformations of 1,3-enynes

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Abstract

A mild and efficient electrochemical strategy has been developed for the multicomponent 1,4-arylalkylation, unsymmetrical dialkylation and hydro(deutero)alkylation of 1,3-enynes with aryl and alkyl bromides as cross-coupling partners. This protocol can be used to synthesize diverse allenes bearing various functionalities, including allenes found in natural products and drugs.

Original language	English (US)
Journal	Nature Synthesis
DOIs	https://doi.org/10.1038/s44160-023-00350-2
State	Published - Jun 22 2023

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KAUST Repository Item: Exported on 2023-07-20

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10.1038/s44160-023-00350-2

https://repository.kaust.edu.sa/bitstream/10754/693116/1/Electrochemical%20synthesis%20of%20diverse%20allenes%20via%20controllable%20transformations%20Accepted%20Manuscript.pdf

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title = "Electrochemical synthesis of diverse allenes through controllable transformations of 1,3-enynes",

abstract = "A mild and efficient electrochemical strategy has been developed for the multicomponent 1,4-arylalkylation, unsymmetrical dialkylation and hydro(deutero)alkylation of 1,3-enynes with aryl and alkyl bromides as cross-coupling partners. This protocol can be used to synthesize diverse allenes bearing various functionalities, including allenes found in natural products and drugs.",

author = "Chen Zhu and Magnus Rueping",

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PY - 2023/6/22

Y1 - 2023/6/22

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AB - A mild and efficient electrochemical strategy has been developed for the multicomponent 1,4-arylalkylation, unsymmetrical dialkylation and hydro(deutero)alkylation of 1,3-enynes with aryl and alkyl bromides as cross-coupling partners. This protocol can be used to synthesize diverse allenes bearing various functionalities, including allenes found in natural products and drugs.

UR - http://hdl.handle.net/10754/693116

UR - https://www.nature.com/articles/s44160-023-00350-2

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M3 - Article

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Electrochemical synthesis of diverse allenes through controllable transformations of 1,3-enynes

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