Electrical detection of DNA hybridization with single-base specificity using transistors based on CVD-grown graphene sheets

Xiaochen Dong; Yumeng Shi; Wei Huang; Peng Chen; Lain Jong Li

doi:10.1002/adma.200903645

Electrical detection of DNA hybridization with single-base specificity using transistors based on CVD-grown graphene sheets

Xiaochen Dong^*, Yumeng Shi, Wei Huang, Peng Chen, Lain Jong Li

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

523 Scopus citations

Abstract

Large-sized chemical vapor deposited graphene films configured as solutiongated transistors can label-freely and electrically detect DNA hybridization with single-base specificity. The gate voltage which gives the minimum device conductance (V_g.min) is sensitive to the charge transfer between DNA molecules and graphene, and thus is used to detect the DNA hybridization. The DNA detection is attributed to the electronic n-doping from DNA to graphene rather than the electrostatic gating effect or impurity screening effect. Chemical Equation Presentation

Original language	English (US)
Pages (from-to)	1649-1653
Number of pages	5
Journal	Advanced Materials
Volume	22
Issue number	14
DOIs	https://doi.org/10.1002/adma.200903645
State	Published - Apr 12 2010
Externally published	Yes

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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abstract = "Large-sized chemical vapor deposited graphene films configured as solutiongated transistors can label-freely and electrically detect DNA hybridization with single-base specificity. The gate voltage which gives the minimum device conductance (Vg.min) is sensitive to the charge transfer between DNA molecules and graphene, and thus is used to detect the DNA hybridization. The DNA detection is attributed to the electronic n-doping from DNA to graphene rather than the electrostatic gating effect or impurity screening effect. Chemical Equation Presentation",

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AU - Huang, Wei

AU - Chen, Peng

AU - Li, Lain Jong

PY - 2010/4/12

Y1 - 2010/4/12

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AB - Large-sized chemical vapor deposited graphene films configured as solutiongated transistors can label-freely and electrically detect DNA hybridization with single-base specificity. The gate voltage which gives the minimum device conductance (Vg.min) is sensitive to the charge transfer between DNA molecules and graphene, and thus is used to detect the DNA hybridization. The DNA detection is attributed to the electronic n-doping from DNA to graphene rather than the electrostatic gating effect or impurity screening effect. Chemical Equation Presentation

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M3 - Article

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Electrical detection of DNA hybridization with single-base specificity using transistors based on CVD-grown graphene sheets

Abstract

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