Efficient and Highly Aldehyde Selective Wacker Oxidation

Peili Teo, Zachary K. Wickens, Guangbin Dong, Robert H. Grubbs

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


A method for efficient and aldehyde-selective Wacker oxidation of aryl-substituted olefins using PdCl 2(MeCN) 2, 1,4-benzoquinone, and t-BuOH in air is described. Up to a 96% yield of aldehyde can be obtained, and up to 99% selectivity can be achieved with styrene-related substrates. © 2012 American Chemical Society.
Original languageEnglish (US)
Pages (from-to)3237-3239
Number of pages3
JournalOrganic Letters
Issue number13
StatePublished - Jun 13 2012
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We gratefully acknowledge financial support from King Abdullah University of Science and Technology Centre in Development, King Fahd University of Petroleum and Minerals, and the NSF. G.D. thanks the Camille and Henry Dreyfus Foundation for a postdoctoral fellowship.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.


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