Effect of 6-hydroxydopamine lesions on norepinephrine-induced [3H]glycogen hydrolysis in mouse cortical slices

Pierre J. Magistretti*, John H. Morrison, William J. Shoemaker, Floyd E. Bloom

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


The effects of norepinephrine (NE) on in vitro [3H]glycogenolysis were assessed in slices of cerebral cortex from mice whose cortical noradrenergic innervation had been severely reduced by intracisternal 6-hydroxydopamine (6-OHDA) injections. A supersensitive response to NE was observed, as demonstrated by a decrease in the EC50 of the catecholamine in the lesioned mice from 533 ± 88 nM to 39.3 ± 7.9 nM. This supersensitive response, observed two weeks after the lesion, was post-synaptic since isoproterenol, a β-adrenergic agonist not accumulated by pre-synaptic uptake mechanisms, also gave an equally supersensitive response.

Original languageEnglish (US)
Pages (from-to)159-162
Number of pages4
JournalBrain Research
Issue number1
StatePublished - Feb 14 1983

Bibliographical note

Funding Information:
The authors would like to thank Ms. Lynne Randolph and Ms. Cathy Cannon for skillful technical assistance, and Ms. Nancy Callahan for typing the manuscript. This work was supported by grants from NIMH 29466. P.J.M. was supported by Swiss National Science Foundation Fellowship 83.832.0.80.


  • adrenergic receptors
  • brain energy metabolism
  • cerebral cortex
  • cyclic-AMP
  • glycogen
  • supersensitivity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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