Early Humoral Response Correlates with Disease Severity and Outcomes in COVID-19 Patients.

Anwar M Hashem; Abdullah Algaissi; Sarah A Almahboub; Mohamed A Alfaleh; Turki S Abujamel; Sawsan S Alamri; Khalid A Alluhaybi; Haya I Hobani; Rahaf H AlHarbi; Reem M Alsulaiman; M-Zaki ElAssouli; Sharif Hala; Naif K Alharbi; Rowa Y Alhabbab; Ahdab A AlSaieedi; Wesam H Abdulaal; Abdullah Bukhari; Afrah A AL-Somali; Fadwa S Alofi; Asim A Khogeer; Arnab Pain; Almohanad A Alkayyal; Naif A M Almontashiri; Bakur Mahmoud Ahmad; Xuguang Li

doi:10.3390/v12121390

Early Humoral Response Correlates with Disease Severity and Outcomes in COVID-19 Patients.

Anwar M Hashem, Abdullah Algaissi, Sarah A Almahboub, Mohamed A Alfaleh, Turki S Abujamel, Sawsan S Alamri, Khalid A Alluhaybi, Haya I Hobani, Rahaf H AlHarbi, Reem M Alsulaiman, M-Zaki ElAssouli, Sharif Hala, Naif K Alharbi, Rowa Y Alhabbab, Ahdab A AlSaieedi, Wesam H Abdulaal, Abdullah Bukhari, Afrah A AL-Somali, Fadwa S Alofi, Asim A KhogeerArnab Pain, Almohanad A Alkayyal, Naif A M Almontashiri, Bakur Mahmoud Ahmad, Xuguang Li

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Abstract

The Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, continues to spread globally with significantly high morbidity and mortality rates. Antigen-specific responses are of unquestionable value for clinical management of COVID-19 patients. Here, we investigated the kinetics of IgM, IgG against the spike (S) and nucleoproteins (N) proteins and their neutralizing capabilities in hospitalized COVID-19 patients with different disease presentations (i.e., mild, moderate or severe), need for intensive care units (ICU) admission or outcomes (i.e., survival vs death). We show that SARS-CoV-2 specific IgG, IgM and neutralizing antibodies (nAbs) were readily detectable in almost all COVID-19 patients with various clinical presentations. Interestingly, significantly higher levels of nAbs as well as anti-S1 and -N IgG and IgM antibodies were found in patients with more severe symptoms, patients requiring admission to ICU or those with fatal outcomes. More importantly, early after symptoms onset, we found that the levels of anti-N antibodies correlated strongly with disease severity. Collectively, these findings provide new insights into the kinetics of antibody responses in COVID-19 patients with different disease severity.

Original language	English (US)
Pages (from-to)	1390
Journal	Viruses
Volume	12
Issue number	12
DOIs	https://doi.org/10.3390/v12121390
State	Published - Dec 9 2020

Bibliographical note

KAUST Repository Item: Exported on 2020-12-16
Acknowledgements: The authors extend their appreciation to the Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia for funding this research.

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10.3390/v12121390

https://repository.kaust.edu.sa/bitstream/10754/666365/1/viruses-12-01390-v2.pdf

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Hashem, A. M., Algaissi, A., Almahboub, S. A., Alfaleh, M. A., Abujamel, T. S., Alamri, S. S., Alluhaybi, K. A., Hobani, H. I., AlHarbi, R. H., Alsulaiman, R. M., ElAssouli, M.-Z., Hala, S., Alharbi, N. K., Alhabbab, R. Y., AlSaieedi, A. A., Abdulaal, W. H., Bukhari, A., AL-Somali, A. A., Alofi, F. S., ... Li, X. (2020). Early Humoral Response Correlates with Disease Severity and Outcomes in COVID-19 Patients. Viruses, 12(12), 1390. https://doi.org/10.3390/v12121390

@article{e3a7d1694831442899028fb90cc41f22,

title = "Early Humoral Response Correlates with Disease Severity and Outcomes in COVID-19 Patients.",

abstract = "The Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, continues to spread globally with significantly high morbidity and mortality rates. Antigen-specific responses are of unquestionable value for clinical management of COVID-19 patients. Here, we investigated the kinetics of IgM, IgG against the spike (S) and nucleoproteins (N) proteins and their neutralizing capabilities in hospitalized COVID-19 patients with different disease presentations (i.e., mild, moderate or severe), need for intensive care units (ICU) admission or outcomes (i.e., survival vs death). We show that SARS-CoV-2 specific IgG, IgM and neutralizing antibodies (nAbs) were readily detectable in almost all COVID-19 patients with various clinical presentations. Interestingly, significantly higher levels of nAbs as well as anti-S1 and -N IgG and IgM antibodies were found in patients with more severe symptoms, patients requiring admission to ICU or those with fatal outcomes. More importantly, early after symptoms onset, we found that the levels of anti-N antibodies correlated strongly with disease severity. Collectively, these findings provide new insights into the kinetics of antibody responses in COVID-19 patients with different disease severity.",

author = "Hashem, {Anwar M} and Abdullah Algaissi and Almahboub, {Sarah A} and Alfaleh, {Mohamed A} and Abujamel, {Turki S} and Alamri, {Sawsan S} and Alluhaybi, {Khalid A} and Hobani, {Haya I} and AlHarbi, {Rahaf H} and Alsulaiman, {Reem M} and M-Zaki ElAssouli and Sharif Hala and Alharbi, {Naif K} and Alhabbab, {Rowa Y} and AlSaieedi, {Ahdab A} and Abdulaal, {Wesam H} and Abdullah Bukhari and AL-Somali, {Afrah A} and Alofi, {Fadwa S} and Khogeer, {Asim A} and Arnab Pain and Alkayyal, {Almohanad A} and Almontashiri, {Naif A M} and Ahmad, {Bakur Mahmoud} and Xuguang Li",

note = "KAUST Repository Item: Exported on 2020-12-16 Acknowledgements: The authors extend their appreciation to the Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia for funding this research.",

year = "2020",

month = dec,

day = "9",

doi = "10.3390/v12121390",

language = "English (US)",

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journal = "Viruses",

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Hashem, AM, Algaissi, A, Almahboub, SA, Alfaleh, MA, Abujamel, TS, Alamri, SS, Alluhaybi, KA, Hobani, HI, AlHarbi, RH, Alsulaiman, RM, ElAssouli, M-Z, Hala, S, Alharbi, NK, Alhabbab, RY, AlSaieedi, AA, Abdulaal, WH, Bukhari, A, AL-Somali, AA, Alofi, FS, Khogeer, AA, Pain, A, Alkayyal, AA, Almontashiri, NAM, Ahmad, BM & Li, X 2020, 'Early Humoral Response Correlates with Disease Severity and Outcomes in COVID-19 Patients.', Viruses, vol. 12, no. 12, pp. 1390. https://doi.org/10.3390/v12121390

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T1 - Early Humoral Response Correlates with Disease Severity and Outcomes in COVID-19 Patients.

AU - Hashem, Anwar M

AU - Algaissi, Abdullah

AU - Almahboub, Sarah A

AU - Alfaleh, Mohamed A

AU - Abujamel, Turki S

AU - Alamri, Sawsan S

AU - Alluhaybi, Khalid A

AU - Hobani, Haya I

AU - AlHarbi, Rahaf H

AU - Alsulaiman, Reem M

AU - ElAssouli, M-Zaki

AU - Hala, Sharif

AU - Alharbi, Naif K

AU - Alhabbab, Rowa Y

AU - AlSaieedi, Ahdab A

AU - Abdulaal, Wesam H

AU - Bukhari, Abdullah

AU - AL-Somali, Afrah A

AU - Alofi, Fadwa S

AU - Khogeer, Asim A

AU - Pain, Arnab

AU - Alkayyal, Almohanad A

AU - Almontashiri, Naif A M

AU - Ahmad, Bakur Mahmoud

AU - Li, Xuguang

N1 - KAUST Repository Item: Exported on 2020-12-16 Acknowledgements: The authors extend their appreciation to the Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia for funding this research.

PY - 2020/12/9

Y1 - 2020/12/9

N2 - The Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, continues to spread globally with significantly high morbidity and mortality rates. Antigen-specific responses are of unquestionable value for clinical management of COVID-19 patients. Here, we investigated the kinetics of IgM, IgG against the spike (S) and nucleoproteins (N) proteins and their neutralizing capabilities in hospitalized COVID-19 patients with different disease presentations (i.e., mild, moderate or severe), need for intensive care units (ICU) admission or outcomes (i.e., survival vs death). We show that SARS-CoV-2 specific IgG, IgM and neutralizing antibodies (nAbs) were readily detectable in almost all COVID-19 patients with various clinical presentations. Interestingly, significantly higher levels of nAbs as well as anti-S1 and -N IgG and IgM antibodies were found in patients with more severe symptoms, patients requiring admission to ICU or those with fatal outcomes. More importantly, early after symptoms onset, we found that the levels of anti-N antibodies correlated strongly with disease severity. Collectively, these findings provide new insights into the kinetics of antibody responses in COVID-19 patients with different disease severity.

AB - The Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, continues to spread globally with significantly high morbidity and mortality rates. Antigen-specific responses are of unquestionable value for clinical management of COVID-19 patients. Here, we investigated the kinetics of IgM, IgG against the spike (S) and nucleoproteins (N) proteins and their neutralizing capabilities in hospitalized COVID-19 patients with different disease presentations (i.e., mild, moderate or severe), need for intensive care units (ICU) admission or outcomes (i.e., survival vs death). We show that SARS-CoV-2 specific IgG, IgM and neutralizing antibodies (nAbs) were readily detectable in almost all COVID-19 patients with various clinical presentations. Interestingly, significantly higher levels of nAbs as well as anti-S1 and -N IgG and IgM antibodies were found in patients with more severe symptoms, patients requiring admission to ICU or those with fatal outcomes. More importantly, early after symptoms onset, we found that the levels of anti-N antibodies correlated strongly with disease severity. Collectively, these findings provide new insights into the kinetics of antibody responses in COVID-19 patients with different disease severity.

UR - http://hdl.handle.net/10754/666365

UR - https://www.mdpi.com/1999-4915/12/12/1390

U2 - 10.3390/v12121390

DO - 10.3390/v12121390

M3 - Article

C2 - 33291713

SN - 1999-4915

VL - 12

SP - 1390

JO - Viruses

JF - Viruses

IS - 12

ER -

Early Humoral Response Correlates with Disease Severity and Outcomes in COVID-19 Patients.

Abstract

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