Dynamic Nef and Nef dynamics: How structure could explain the complex activities of this small HIV protein

Stefan T. Arold; Andreas S. Baur

doi:10.1016/S0968-0004(01)01846-1

Dynamic Nef and Nef dynamics: How structure could explain the complex activities of this small HIV protein

Stefan T. Arold^*, Andreas S. Baur

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

134 Scopus citations

Abstract

The Nef protein of the human immunodeficiency virus is as important for disease progression as it is perplexing in its plethora of target molecules and functions. In this article, it is proposed that the complex biology of Nef is regulated through conformational changes of the protein that are triggered by cellular location and specific interactions as Nef traffics through the infected cell.

Original language	English (US)
Pages (from-to)	356-363
Number of pages	8
Journal	Trends in Biochemical Sciences
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/S0968-0004(01)01846-1
State	Published - Jun 1 2001
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0968-0004(01)01846-1

Cite this

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title = "Dynamic Nef and Nef dynamics: How structure could explain the complex activities of this small HIV protein",

abstract = "The Nef protein of the human immunodeficiency virus is as important for disease progression as it is perplexing in its plethora of target molecules and functions. In this article, it is proposed that the complex biology of Nef is regulated through conformational changes of the protein that are triggered by cellular location and specific interactions as Nef traffics through the infected cell.",

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AU - Arold, Stefan T.

AU - Baur, Andreas S.

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Y1 - 2001/6/1

N2 - The Nef protein of the human immunodeficiency virus is as important for disease progression as it is perplexing in its plethora of target molecules and functions. In this article, it is proposed that the complex biology of Nef is regulated through conformational changes of the protein that are triggered by cellular location and specific interactions as Nef traffics through the infected cell.

AB - The Nef protein of the human immunodeficiency virus is as important for disease progression as it is perplexing in its plethora of target molecules and functions. In this article, it is proposed that the complex biology of Nef is regulated through conformational changes of the protein that are triggered by cellular location and specific interactions as Nef traffics through the infected cell.

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U2 - 10.1016/S0968-0004(01)01846-1

DO - 10.1016/S0968-0004(01)01846-1

M3 - Review article

C2 - 11406408

AN - SCOPUS:0035368515

SN - 0968-0004

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EP - 363

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 6

ER -

Dynamic Nef and Nef dynamics: How structure could explain the complex activities of this small HIV protein

Abstract

ASJC Scopus subject areas

UN SDGs

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