A method for the synthesis of 2,3,6,7-substituted anthracene derivatives, one of the most challenging anthracene substitution patterns to obtain, is presented. The method is exemplified by the preparation of 2,3,6,7-anthracenetetracarbonitrile and employs a newly developed, stable, protected 1,2,4,5-benzenetetracarbaldehyde as the precursor. The precursor can be obtained in two scalable synthetic steps from 2,5-dibromoterephthalaldehyde and is converted into the anthracene derivative by a double intermolecular Wittig reaction under very mild conditions, followed by a deprotection and intramolecular double ring-closing condensation reaction.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Organic Chemistry|
|State||Published - Jun 19 2020|
Bibliographical noteGenerated from Scopus record by KAUST IRTS on 2023-02-14
ASJC Scopus subject areas
- Organic Chemistry