Does the intrinsic instability of aneuploid genomes have a causal role in cancer?

Marjori A. Matzke; M. Florian Mette; Tatsuo Kanno; Antonius J.M. Matzke

doi:10.1016/S0168-9525(03)00057-X

Does the intrinsic instability of aneuploid genomes have a causal role in cancer?

Marjori A. Matzke, M. Florian Mette, Tatsuo Kanno, Antonius J.M. Matzke

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

The role of aneuploidy in carcinogenesis has long been debated. We argue here that aneuploid genomes are naturally more susceptible to the types of chromosome rearrangement and epigenetic aberration that are found typically in tumor cells. In some cases, the formation of an aneuploid genome might be the initiating step in neoplastic conversion.

Original language	English (US)
Pages (from-to)	253-256
Number of pages	4
Journal	Trends in Genetics
Volume	19
Issue number	5
DOIs	https://doi.org/10.1016/S0168-9525(03)00057-X
State	Published - May 1 2003
Externally published	Yes

ASJC Scopus subject areas

Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0168-9525(03)00057-X

Cite this

@article{d5005ed4bdb74768af1efba19e52d114,

title = "Does the intrinsic instability of aneuploid genomes have a causal role in cancer?",

abstract = "The role of aneuploidy in carcinogenesis has long been debated. We argue here that aneuploid genomes are naturally more susceptible to the types of chromosome rearrangement and epigenetic aberration that are found typically in tumor cells. In some cases, the formation of an aneuploid genome might be the initiating step in neoplastic conversion.",

author = "Matzke, {Marjori A.} and Mette, {M. Florian} and Tatsuo Kanno and Matzke, {Antonius J.M.}",

year = "2003",

month = may,

day = "1",

doi = "10.1016/S0168-9525(03)00057-X",

language = "English (US)",

volume = "19",

pages = "253--256",

journal = "Trends in Genetics",

issn = "0168-9525",