TY - JOUR
T1 - Distribution of serotypes and evaluation of antimicrobial susceptibility among human and bovine Streptococcus agalactiae strains isolated in Brazil between 1980 and 2006
AU - Pinto, Tatiana Castro Abreu
AU - Costa, Natália Silva
AU - Vianna Souza, Aline Rosa
AU - Da Silva, Ligia Guedes
AU - Corrêa, Ana Beatriz de Almeida
AU - Fernandes, Flavio Gimenis
AU - Oliveira, Ivi Cristina Menezes
AU - De Mattos, Marcos Corrêa
AU - Rosado, Alexandre Soares
AU - Benchetrit, Leslie Claude
N1 - Generated from Scopus record by KAUST IRTS on 2021-02-16
PY - 2013/3/1
Y1 - 2013/3/1
N2 - Streptococcus agalactiae is a common agent of clinical and subclinical bovine mastitis and an important cause of human infections, mainly among pregnant women, neonates and nonpregnant adults with underlying diseases. The present study describes the genetic and phenotypic diversity among 392 S. agalactiae human and bovine strains isolated between 1980 and 2006 in Brazil. The most prevalent serotypes were Ia, II, III and V and all the strains were susceptible to penicillin, vancomycin and levofloxacin. Resistance to clindamycin, chloramphenicol, erythromycin, rifampicin and tetracycline was observed. Among the erythromycin resistant strains, mefA/E, ermA and, mainly, ermB gene were detected, and a shift of prevalence from the macrolide resistance phenotype to the macrolide-lincosamide-streptogramin B resistance phenotype over the years was observed. The 23 macrolide-resistant strains showed 19 different pulsed-field gel electrophoresis profiles. Regarding macrolide resistance, a major concern in S. agalactiae epidemiology, the present study describes an increase in erythromycin resistance from the 80s to the 90s followed by a decrease in the 2000-2006 period. Also, the genetic heterogeneity described points out that erythromycin resistance in Brazil is rather due to horizontal gene transmission than to spreading of specific macrolide-resistant clones. © 2013 Elsevier Editora Ltda.
AB - Streptococcus agalactiae is a common agent of clinical and subclinical bovine mastitis and an important cause of human infections, mainly among pregnant women, neonates and nonpregnant adults with underlying diseases. The present study describes the genetic and phenotypic diversity among 392 S. agalactiae human and bovine strains isolated between 1980 and 2006 in Brazil. The most prevalent serotypes were Ia, II, III and V and all the strains were susceptible to penicillin, vancomycin and levofloxacin. Resistance to clindamycin, chloramphenicol, erythromycin, rifampicin and tetracycline was observed. Among the erythromycin resistant strains, mefA/E, ermA and, mainly, ermB gene were detected, and a shift of prevalence from the macrolide resistance phenotype to the macrolide-lincosamide-streptogramin B resistance phenotype over the years was observed. The 23 macrolide-resistant strains showed 19 different pulsed-field gel electrophoresis profiles. Regarding macrolide resistance, a major concern in S. agalactiae epidemiology, the present study describes an increase in erythromycin resistance from the 80s to the 90s followed by a decrease in the 2000-2006 period. Also, the genetic heterogeneity described points out that erythromycin resistance in Brazil is rather due to horizontal gene transmission than to spreading of specific macrolide-resistant clones. © 2013 Elsevier Editora Ltda.
UR - https://linkinghub.elsevier.com/retrieve/pii/S1413867013000226
UR - http://www.scopus.com/inward/record.url?scp=84876739487&partnerID=8YFLogxK
U2 - 10.1016/j.bjid.2012.09.006
DO - 10.1016/j.bjid.2012.09.006
M3 - Article
SN - 1413-8670
VL - 17
SP - 131
EP - 136
JO - Brazilian Journal of Infectious Diseases
JF - Brazilian Journal of Infectious Diseases
IS - 2
ER -
