Abstract
The protein interactome mediates crucial functions in transcription, chromatin remodeling, and higher-order structural organization. Elucidating the proteins that interact with chromatin-associated RNA or proteins is key to understanding fundamental epigenetic regulatory pathways. We discuss the opportunities and challenges of mass spectrometry (MS)-based proteomics for characterizing the plant chromatin interactome.
Original language | English (US) |
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Pages (from-to) | 261-265 |
Number of pages | 5 |
Journal | Trends in biotechnology |
Volume | 40 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2022 |
Bibliographical note
Funding Information:Dr Joshua L. Heazlewood (The University of Melbourne) is acknowledged for proof reading the article. Our work was supported by grants from National Natural Science Foundation of China ( 31470345 to Y.C. and 31970529 to J.X.).
Funding Information:
Dr Joshua L. Heazlewood (The University of Melbourne) is acknowledged for proof reading the article. Our work was supported by grants from National Natural Science Foundation of China (31470345 to Y.C. and 31970529 to J.X.). We also extend our special thanks to Dr Valerio Orlando (King Abdullah University of Science and Technology) for his conceptual recommendations to this article. The research of the P.L. was supported by KAUST Office of Sponsored Research (OSR), under award numbers BAS/1/1037-01-01 and URF/1/4042. The authors declare no conflicts of interest.
Publisher Copyright:
© 2021 Elsevier Ltd
Keywords
- chromatin
- epigenetics
- interactome
- proteomics
- RNA-binding protein
ASJC Scopus subject areas
- Biotechnology
- Bioengineering