Dissecting the plant chromatin interactome using mass spectrometry

Yanmei Chen*, Jun Xiao, Peng Liu

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

Abstract

The protein interactome mediates crucial functions in transcription, chromatin remodeling, and higher-order structural organization. Elucidating the proteins that interact with chromatin-associated RNA or proteins is key to understanding fundamental epigenetic regulatory pathways. We discuss the opportunities and challenges of mass spectrometry (MS)-based proteomics for characterizing the plant chromatin interactome.

Original languageEnglish (US)
Pages (from-to)261-265
Number of pages5
JournalTrends in biotechnology
Volume40
Issue number3
DOIs
StatePublished - Mar 2022

Bibliographical note

Funding Information:
Dr Joshua L. Heazlewood (The University of Melbourne) is acknowledged for proof reading the article. Our work was supported by grants from National Natural Science Foundation of China ( 31470345 to Y.C. and 31970529 to J.X.).

Funding Information:
Dr Joshua L. Heazlewood (The University of Melbourne) is acknowledged for proof reading the article. Our work was supported by grants from National Natural Science Foundation of China (31470345 to Y.C. and 31970529 to J.X.). We also extend our special thanks to Dr Valerio Orlando (King Abdullah University of Science and Technology) for his conceptual recommendations to this article. The research of the P.L. was supported by KAUST Office of Sponsored Research (OSR), under award numbers BAS/1/1037-01-01 and URF/1/4042. The authors declare no conflicts of interest.

Publisher Copyright:
© 2021 Elsevier Ltd

Keywords

  • chromatin
  • epigenetics
  • interactome
  • proteomics
  • RNA-binding protein

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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