Directing Group Guided Site-Selective Diversification of Indoles by Aziridine: Synthesis of β-Indolylethylamines

Ashfaq Ahmad, Himangsu Sekhar Dutta, Mohit Kumar, Raziullah, Manoj Kumar Gangwar, Dipankar Koley

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A palladium catalyzed directing group assisted cross-coupling of aliphatic aziridines with indole, indoline, tetrahydroquinoline, and aniline has been developed to furnish the corresponding β-arylethylamine derivatives. The substrate scope was very general, and the protocol was also tolerated in the presence of various external additives. Control experiments suggested that the C-H cleavage step is the rate-determining step.
Original languageEnglish (US)
JournalOrganic Letters
DOIs
StatePublished - Apr 8 2022

Bibliographical note

KAUST Repository Item: Exported on 2022-04-18
Acknowledgements: Financial support from DST-SERB (EMR/2016/000613), CSIR, and UGC-New Delhi (A.A., H.S.D., M.K., and R.) is gratefully acknowledged. We thank the CDRI SAIF division for analytical support. CDRI communication no 10389

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry

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