Directed assembly of discrete gold nanoparticle groupings using branched DNA scaffolds

Shelley A. Claridge, Sarah L. Goh, Jean M.J. Fréchet, Shara C. Williams, Christine M. Micheel, A. Paul Alivisatos

Research output: Contribution to journalArticlepeer-review

146 Scopus citations


The concept of self-assembled dendrimers is explored for the creation of discrete nanoparticle assemblies. Hybridization of branched DNA trimers and nanoparticle-DNA conjugates results in the synthesis of nanoparticle trimer and tetramer complexes. Multiple tetramer architectures are investigated, utilizing Au-DNA conjugates with varying secondary structural motifs. Hybridization products are analyzed by gel electrophoresis, and discrete bands are observed corresponding to structures with increasing numbers of hybridization events. Samples extracted from each band are analyzed by transmission electron microscopy, and statistics compiled from micrographs are used to compare assembly characteristics for each architecture. Asymmetric structures are also produced in which both 5- and 10-nm Au particles are assembled on branched scaffolds.

Original languageEnglish (US)
Pages (from-to)1628-1635
Number of pages8
JournalChemistry of Materials
Issue number7
StatePublished - Apr 5 2005
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering
  • Materials Chemistry


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