Direct Cross-Coupling of Allylic C(sp3
)−H Bonds with Aryl- and Vinylbromides by Combined Nickel and Visible-Light Catalysis

Long Huang; Magnus Rueping

doi:10.1002/anie.201805118

Direct Cross-Coupling of Allylic C(sp3 )−H Bonds with Aryl- and Vinylbromides by Combined Nickel and Visible-Light Catalysis

Long Huang, Magnus Rueping

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

An efficient protocol for the direct allylic C(sp3)−H bond activation of unactivated tri- and tetrasubstituted alkenes and their functionalization with aryl- and vinylbromides by nickel and visible-light photocatalysis has been developed. The method allows C(sp2)−C(sp3) formation under mild reaction conditions with good functional-group tolerance and excellent regioselectivity.

Original language	English (US)
Pages (from-to)	10333-10337
Number of pages	5
Journal	Angewandte Chemie International Edition
Volume	57
Issue number	32
DOIs	https://doi.org/10.1002/anie.201805118 https://doi.org/10.1002/ange.201805118
State	Published - Jul 16 2018

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ ERC Grant Agreement no. 617044 (SunCatChem).

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title = "Direct Cross-Coupling of Allylic C(sp3 )−H Bonds with Aryl- and Vinylbromides by Combined Nickel and Visible-Light Catalysis",

abstract = "An efficient protocol for the direct allylic C(sp3)−H bond activation of unactivated tri- and tetrasubstituted alkenes and their functionalization with aryl- and vinylbromides by nickel and visible-light photocatalysis has been developed. The method allows C(sp2)−C(sp3) formation under mild reaction conditions with good functional-group tolerance and excellent regioselectivity.",

author = "Long Huang and Magnus Rueping",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ ERC Grant Agreement no. 617044 (SunCatChem).",

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AU - Rueping, Magnus

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ ERC Grant Agreement no. 617044 (SunCatChem).

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AB - An efficient protocol for the direct allylic C(sp3)−H bond activation of unactivated tri- and tetrasubstituted alkenes and their functionalization with aryl- and vinylbromides by nickel and visible-light photocatalysis has been developed. The method allows C(sp2)−C(sp3) formation under mild reaction conditions with good functional-group tolerance and excellent regioselectivity.

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ER -

Direct Cross-Coupling of Allylic C(sp3 )−H Bonds with Aryl- and Vinylbromides by Combined Nickel and Visible-Light Catalysis

Abstract

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