Dipeptide-Based Photoreactive Instant Glue for Environmental and Biomedical Applications

Panayiotis Bilalis, Abdulelah I. Alrashoudi, Hepi H. Susapto, Manola Moretti, Salwa Alshehri, Sherin Abdelrahman, Amr Elsakran, Charlotte A.E. Hauser*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Nature-inspired smart materials offer numerous advantages over environmental friendliness and efficiency. Emulating the excellent adhesive properties of mussels foot proteins, where the lysine is in close proximity with the 3,4-dihydroxy-l-phenylalanine (DOPA), we report the synthesis of a novel photocurable peptide-based adhesive consisting exclusively of these two amino acids. Our adhesive is a highly concentrated aqueous solution of a monomer, a cross-linker, and a photoinitiator. Lap-shear adhesion measurements on plastic and glass surfaces and comparison with different types of commercial adhesives showed that the adhesive strength of our glue is comparable when applied in air and superior when used underwater. No toxicity of our adhesive was observed when the cytocompatibility on human dermal fibroblast cells was assessed. Preliminary experiments with various tissues and coral fragments showed that our adhesive could be applied to wound healing and coral reef restoration. Given the convenience of the facile synthesis, biocompatibility, ease of application underwater, and high adhesive strength, we expect that our adhesive may find application, but not limited, to the biomedical and environmental field.

Original languageEnglish (US)
Pages (from-to)46710-46720
Number of pages11
JournalACS Applied Materials and Interfaces
Issue number40
StateAccepted/In press - 2023

Bibliographical note

Publisher Copyright:
© 2023 American Chemical Society.


  • coral restoration
  • dipeptide-based glue
  • DOPA
  • lysine-DOPA synergy
  • photopolymerization
  • strong adhesive
  • underwater application

ASJC Scopus subject areas

  • General Materials Science


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